Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 6, Issue 23, Pages 3884-3893Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8tb00620b
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Funding
- National Key R&D Program of China [2017YFC1103300]
- National Natural Science Foundation of China [51703230, 21474123]
- Presidential Foundation of the Technical Institute of Physics and Chemistry
- Youth Innovation Promotion Association of the Chinese Academy of Sciences [2017039]
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Infection control and the promotion of healing are two key factors during the wound repair process. However, it is still a major challenge for one material to inhibit bacterial growth efficiently and promote wound healing at the same time. Here, a bifunctional chitosan derivative (CS-G/mPEG) was prepared by the successive modification of chitosan with carboxymethoxypolyethylene glycol (mPEG-COOH) and aminoiminomethanesulfonic acid (AIMSOA). We demonstrated that CS-G/mPEG can selectively disrupt bacterial membranes with high efficiency and thus kill Gram-positive bacteria without inducing hemolysis or cytotoxicity. In rats with full-thickness skin wounds infected with Staphylococcus aureus bacteria, CS-G/mPEG inhibited the growth of the bacteria and accelerated the healing of the wounds. Owing to the balance between the antimicrobial activity and biological safety of CS-G/mPEG, this bifunctional chitosan derivative is promising as an ideal anti-infective wound-repairing material for managing wounds with Gram-positive bacterial infections.
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