Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 6, Issue 15, Pages 2258-2273Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8tb00132d
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Funding
- Natural Science Foundation of China [51403137]
- Young teachers' scientific research foundation of Sichuan University [2014SCU11015]
- Fundamental Research Funds for the Central Universities [2012017yjsy223]
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Limited active sites in polyesters hinder fabrication of multifunctional biodegradable nanocarriers for successful clinical applications. Herein, poly(malic acid) (PMA)-based biodegradable polyesters bearing large carboxyl groups in their side chains were grafted with intracellular reductive-sensitive polyethylene glycol and imidazole to construct bioreducible nanocarriers (PLM-g-ss-EGA). The uniform spherical shape and high stability of the PLM-g-ss-EGA nanocarriers were demonstrated by dynamic light scattering (DLS) and dissipative particle dynamics (DPD) simulations. Enhanced interaction between the monomers in this novel nanocarrier doubled its drug loading efficiency (15%) as compared to that of traditional polyester nanocarriers (5-7%). Moreover, stimulus-responsive assessment and in vitro drug release studies showed that these bioreducible nanocarriers can balance extracellular stability in blood circulation and intracellular on demand'' release. In vitro and in vivo assays have demonstrated that these bioreducible nanocarriers not only can substantially enhance antitumor efficacy as compared to insensitive micelles and even comparably to free DOX center dot HCl, but can also greatly reduce unwanted side effects in other organs. The encouraging anticancer efficiency of these poly(malic acid)-based nanocarriers opens a new avenue to design multifunctional biodegradable polyester drug-delivery systems.
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