Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 6, Issue 11, Pages 1688-1698Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8tb00148k
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Funding
- National Natural Science Foundation of China [51573039, 51273058, 81372712]
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Imaging-guided photodynamic/photothermal (PDT/PTT) synergetic therapy is important in more precise and efficient cancer treatment. Herein, gadolinium-chelated porphyrin-protein composite based on gold nanorods (GNRs@BPP-Gd) was synthesized through a straightforward and environmentally friendly method. Based on the high longitudinal relaxivity (9.544 mM(-1) s(-1)), GNRs@BPP-Gd can serve as a decent T-1-weighted magnetic resonance imaging (MRI) probe to steer treatment. A relevant cellular uptake assay showed that GNRs@BPP-Gd could be internalized into cancer cells effectively with negligible cytotoxicity. Furthermore, MRI-guided PDT/PTT studies in vivo indicated that GNRs@BPP-Gd could efficiently take effect after intravenous injection, leading to almost complete ablation at the tumor site. A single treatment was conducted for comparison with the combined treatment, indicating that synergetic therapy greatly enhanced the anti-tumor effect.
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