Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 6, Issue 14, Pages 2057-2064Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8tb00371h
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Funding
- National Natural Science Foundation of China [21636010, 21476266]
- China Postdoctoral Science Foundation [2017M620357]
- Postdoctoral Science Foundation of Central South University [185654]
- State Key Laboratory of Powder Metallurgy, Central South University, Changsha, China
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Two dimensional (2D) semiconducting nanomaterials have shown great potential for antitumor therapy. However, their clinical applications are seriously hampered by the tumour microenvironments. Bearing this in mind, we propose to improve the performance of 2D semiconducting nanomaterials using artificial catalase. In this work, we decorate black phosphorus (BP) nanosheets with Pt nanoparticles (NPs) through an in situ growth strategy. Pt NPs as artificial catalases can efficiently decompose the accumulated H2O2 in tumours to relieve tumour hypoxia, and thereafter improve the photodynamic antitumor activity of BP nanosheets. This work paves a new avenue for the functionalization of 2D semiconducting nanomaterials, which will promote the development of 2D semiconductor based nanodrugs.
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