Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 6, Issue 10, Pages 1508-1518Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7tb03148c
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Funding
- National Natural Science Foundation of China [81471657, 81527901]
- 1000 Plan for Young Talents
- Jiangsu Specially Appointed Professorship
- Jiangsu Provincial program for innovative and entrepreneurial talents
- Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection
- Priority Academic Development Program of Jiangsu Higher Education Institutions (PAPD)
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Near-infrared (NIR) long lasting persistent luminescence nanoparticles (PLNPs) have attracted considerable attention in the area of in vivo bioimaging, due to their background-free luminescence characteristics and deep tissue penetration. However, the low fluorescence quantum yield and short afterglow of the currently available PLNPs limit their applications. Here, water-soluble Cr3+-doped ZnGa2O4 PLNPs with the highest quantum yield (eta = 20%) ever reported, bright NIR emission, and excellent colloidal stability were successfully prepared by a one-step hydrothermal method. The afterglow of the resultant nanocrystals lasted for more than 5 days and could be repeatedly reactivated by the light (lambda = 657 nm) of a portable light emitting diode lamp after decay. These nanocrystals were functionalized with alpha, omega-dicarboxyl-terminated poly(ethylene glycol) and poly(acrylic acid) to improve their stability and biocompatibility, so that they could be conjugated with a c(RGDyK) peptide and labeled with Tc-99m for targeted imaging of orthotopic breast cancer by afterglow luminescence imaging and single-photon emission computed tomography imaging. Our NIR-PLNP probes can effectively avoid tissue auto-fluorescence and the light scattering caused by continuous excitation during the diagnosis of cancer.
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