Journal
JOURNAL OF PHARMACY AND BIOALLIED SCIENCES
Volume 4, Issue 5, Pages S14-S16Publisher
MEDKNOW PUBLICATIONS & MEDIA PVT LTD
DOI: 10.4103/0975-7406.94121
Keywords
Drug entrapment; estrogen; solvent emulsification; zeta potential
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The objective of this study was to increase the oral bioavailability of Raloxifene having an absolute bioavailability only 2% due to extensive first pass hepatic metabolism by incorporating it in Solid Lipid Nanoparticles (SLNs). The optimized RSLNs prepared by Ultrasonic Emulsification and Low Temperature Solidification method showed the mean particle size, zeta potential and percentage drug entrapment of 101.4 +/- 3.5 nm, 19.4 +/- 0.279 mv, 97.67 +/- 1.02% respectively. The in-vitro intestinal permeability study indicated significantly higher permeation of the RSLNs than the marketed preparation. The in-vivo studies showed that pharmacokinetic parameters for the RSLNs were 3.5 times higher than the marketed preparation indicating significant increase in the oral bioavailability of the Raloxifene.
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