Journal
NATURE REVIEWS IMMUNOLOGY
Volume 12, Issue 3, Pages 157-167Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri3155
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Funding
- NIAID NIH HHS [R01 AI079187] Funding Source: Medline
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The generation of regulatory T (T-Reg) cells in the thymus is crucial for immune homeostasis and self-tolerance. Recent discoveries have revealed the cellular and molecular mechanisms that govern the differentiation of a subset of developing thymocytes into natural T-Reg cells. Several models, centred on the self-reactivity of the T cell receptor (TCR), have been proposed to explain the generation of a T-Reg cell population that is cognizant of self. Several molecular pathways link TCR and cytokine signalling with the expression of the T-Reg cell-associated transcription factor forkhead box P3 (FOXP3). Moreover, interplay between thymocytes and thymic antigen-presenting cells is also involved in T-Reg cell generation.
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