Journal
NATURE REVIEWS CANCER
Volume 12, Issue 3, Pages 181-195Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3214
Keywords
-
Categories
Funding
- US National Institutes of Health [CA124533, CA126826, CA141029, CA140369, AA018863, R01CA148828]
- National Cancer Institute [ZIABC005561, ZIABC005562, ZIABC005708]
Ask authors/readers for more resources
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that are involved in regulating glucose and lipid homeostasis, inflammation, proliferation and differentiation. Although all of these functions might contribute to the influence of PPARs in carcinogenesis, there is a distinct need for a review of the literature and additional experimentation to determine the potential for targeting PPARs for cancer therapy and cancer chemoprevention. As PPAR agonists include drugs that are used for the treatment of metabolic diseases, a more complete understanding of the roles of PPARs in cancer will aid in determining any increased cancer risk for patients undergoing therapy with PPAR agonists.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available