Journal
HEART FAILURE CLINICS
Volume 14, Issue 3, Pages 237-+Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.hfc.2018.02.001
Keywords
Right heart failure; Pulmonary hypertension; Right ventricular function adaptation; Reduced ejection fraction; Right heart pulmonary circulation
Categories
Funding
- Actelion
- Bayer
- GSK
- Pfizer
- United Therapeutics
- Merck Sharpe Dohme
- Dompe
- Glaxo SmithKline
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The most common cause of failure of the right side of the heart is increased afterload caused by pulmonary hypertension. Right ventricular function adaptation to increased afterload is basically systolic, with secondary increase in dimensions and systemic congestion. Increased right ventricular dimensions and decreased ejection fraction are associated with a decreased survival in severe pulmonary hypertension. Targeted therapies titrated to reverse the right ventricular remodeling dimensions improve survival in severe pulmonary hypertension.
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