Journal
HEART FAILURE CLINICS
Volume 14, Issue 1, Pages 109-+Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.hfc.2017.08.011
Keywords
Heart failure metabolomics; Arginine; Nitric oxide; Myocardial energy utilization; Acylcarnitine; TMAO
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Funding
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL126827, P20HL113452] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK106000] Funding Source: NIH RePORTER
- NHLBI NIH HHS [P20 HL113452, R01 HL126827] Funding Source: Medline
- NIDDK NIH HHS [R01 DK106000] Funding Source: Medline
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Metabolomics is the study of small, organic molecules within biochemical pathways. With advancement of technology, nuclear magnetic resonance, gas chromatography, and mass spectrometry have allowed for the discovery and analysis of large databases of metabolites implicated in heart failure. Metabolomics also explores the patient and environmental interactions and unlocks the link between environmental exposures and the development of cardiovascular disease. Although a relatively new field, metabolomics is poised to become a clinically impactful field that develops novel biomarkers and explores new therapeutic interventions in heart failure.
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