Journal
GENETICS
Volume 209, Issue 4, Pages 1155-1166Publisher
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.118.301137
Keywords
germline stem cells; adipocytes; collagen IV; oogenesis; Drosophila
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Funding
- Bloomington Stock Center [National Institutes of Health (NIH)] [P40 OD-018537]
- NIH [R01 GM-069875, T32 CA-009110, F32 GM-119199]
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Stem cells reside in specialized niches and are regulated by a variety of physiological inputs. Adipocytes influence whole-body physiology and stem cell lineages; however, the molecular mechanisms linking adipocytes to stem cells are poorly understood. Here, we report that collagen IV produced in adipocytes is transported to the ovary to maintain proper germline stem cell (GSC) number in adult Drosophila females. Adipocyte-derived collagen IV acts through -integrin signaling to maintain normal levels of E-cadherin at the niche, thereby ensuring proper adhesion to GSCs. These findings demonstrate that extracellular matrix components produced in adipocytes can be transported to and incorporated into an established adult tissue to influence stem cell number.
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