Journal
IEEE TRANSACTIONS ON MEDICAL IMAGING
Volume 34, Issue 5, Pages 1077-1084Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TMI.2014.2375065
Keywords
Biomedical imaging; magnetic particle imaging; superparamagnetic iron oxides
Categories
Funding
- National Institutes of Health (NIH) [1R01EB013689-01/NIBIB, 2R42EB013520-02A1]
- National Science Foundation (NSF) [IIP-1215556]
- University of Washington/Commercialization Gap Fund (UW/CGF) commercialization grant
- Commercialization Fellowship
- German Federal Ministry of Education and Research (BMBF) [FKZ 13N9079, 13N11086]
- CIRM Tools and Technology [RT2-01893]
- UC
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Magnetic particle imaging (MPI) shows promise for medical imaging, particularly in angiography of patients with chronic kidney disease. As the first biomedical imaging technique that truly depends on nanoscale materials properties, MPI requires highly optimized magnetic nanoparticle tracers to generate quality images. Until now, researchers have relied on tracers optimized for MRI T2*-weighted imaging that are sub-optimal for MPI. Here, we describe new tracers tailored to MPI's unique physics, synthesized using an organic-phase process and functionalized to ensure biocompatibility and adequate in vivo circulation time. Tailored tracers showed up to 3 x greater signal-to-noise ratio and better spatial resolution than existing commercial tracers in MPI images of phantoms.
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