Journal
CLINICAL EPIGENETICS
Volume 10, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s13148-018-0492-1
Keywords
Cancer; Circulating microRNA; Biomarker; Diagnosis; Prognosis
Categories
Funding
- National Natural Science Foundation of China (NSFC) [91749107, 81672091]
- Beijing Natural Science Foundation (BJNSF) [7172232]
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MicroRNAs are endogenous single-stranded non-coding small RNA molecules that can be secreted into the circulation and exist stably. They usually exhibit aberrant expression under different physiological and pathological conditions. Recently, differentially expressed circulating microRNAs were focused on as potential biomarkers for cancer screening. We herein review the role of circulating microRNAs for cancer diagnosis, tumor subtype classification, chemo-or radio-resistance monitoring, and outcome prognosis. Moreover, circulating microRNAs still have several issues hindering their reliability for the practical clinical application. Future studies need to elucidate further potential application of circulating microRNAs as specific and sensitive markers for clinical diagnosis or prognosis in cancers.
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