Journal
BMJ-BRITISH MEDICAL JOURNAL
Volume 362, Issue -, Pages -Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/bmj.k601
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Funding
- Medical Research Council (MRC)
- University of Bristol fund the MRC Integrative Epidemiology Unit [MC_UU_12013/1, MC_UU_12013/9]
- Economics and Social Research Council via a Future Research Leaders Fellowship [ES/N000757/1]
- MRC
- British Heart Foundation Intermediate Clinical Research Fellowship [FS/18/23/33512]
- National Institute for Health Research Oxford Biomedical Research Centre
- ESRC [ES/N000757/1] Funding Source: UKRI
- MRC [MC_UU_12013/1, MC_UU_12013/9] Funding Source: UKRI
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Mendelian randomisation uses genetic variation as a natural experiment to investigate the causal relations between potentially modifiable risk factors and health outcomes in observational data. As with all epidemiological approaches, findings from Mendelian randomisation studies depend on specific assumptions. We provide explanations of the information typically reported in Mendelian randomisation studies that can be used to assess the plausibility of these assumptions and guidance on how to interpret findings from Mendelian randomisation studies in the context of other sources of evidence
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