Journal
BIOMED RESEARCH INTERNATIONAL
Volume 2018, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2018/8126208
Keywords
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Funding
- Key Research Project of Science Technology Department of Zhejiang Province [2015C03030]
- Science Technology Department of Zhejiang Province [2016C33116]
- National Natural Science Foundation of China [81772575, 81502463]
- Key Project of Health Bureau of Zhejiang Province [2018274734]
- Natural Science Foundation of Zhejiang Province [Y15H160158, Q15H070012]
- CSCO Merck Serono Oncology Research Fund, SCORE [Y-MX2015-038]
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Hepatocellular carcinoma (HCC) has the second highest mortality rateworldwide among all cancers. Previous studies have revealed the significant involvement of long noncoding RNAs (lncRNAs) in numerous human cancers including HCC. Both oncogenic and tumor repressive lncRNAs have been identified and implicated in the complex process of hepatocarcinogenesis. They can be further explored as prospective diagnostic, prognostic, and therapeutic markers for HCC. An in-depth understanding of lncRNAs' mechanism in HCC is therefore required to fully explore their potential role. In the current review, we will concentrate on the underlying function, molecular mechanisms, and potential clinical implications of lncRNA in HCC.
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