Journal
BIOMATERIALS SCIENCE
Volume 6, Issue 4, Pages 779-784Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7bm00818j
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Funding
- AcRF tier 2 grant from Ministry of Education (Singapore) [MOE 2014-T2-1-003]
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Hydrogen sulfide (H2S), being an important gaseous signaling molecule, has been gaining increasing attention for its involvement in a wide range of physiological processes. Herein, we developed a novel fluorescence turn-on nanoprobe for selective and sensitive detection of H2S based on graphene quantum dots (GQDs) conjugated with (2,4-dinitrophenoxy) tyrosine (DNPTYR). Taking advantage of its high fluorescence quantum yield, biocompatibility, photostability, and ease to be uptaken by cells, the GQD-based fluorescence probe was further employed for real-time monitoring of the triggered dynamic change of the intracellular H2S level in live cells.
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