Journal
ASIAN JOURNAL OF ORGANIC CHEMISTRY
Volume 7, Issue 7, Pages 1256-1269Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.201800201
Keywords
direct functionalization; early transition metals; lanthanides; metallacycles; synthetic methods
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Funding
- JSPS KAKENHI [JP26248028]
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This review focuses on direct C-H bond functionalization reactions of N-heteroaromatic compounds by group 3 and 4 organometallic complexes. Early transition-metal-carbon and -nitrogen bonds are highly reactive to C-H bond activation via a sigma-bond metathesis pathway to form new organometallic species. By further inserting other unsaturated molecules into the new metal-carbon bond, C-H bond functionalized products are selectively obtained. To clarify the reaction mechanism, we categorize the reaction by the chelation size of the metallacycle intermediate generated from the organometallic species with N-heteroaromatic compounds, and include both stoichiometric and catalytic reactions with their reaction mechanism.
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