Journal
ASIAN JOURNAL OF ORGANIC CHEMISTRY
Volume 7, Issue 8, Pages 1571-1574Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.201800228
Keywords
formylation; N,N-substituted anilines; oxidant-induced; regioselectivity
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Funding
- National Natural Science Foundation of China [21702081, 21702150]
- China Postdoctoral Science Foundation [BX201600114, 2016M602340]
- Jiangxi Provincial Education Department Foundation [GJJ160325]
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Selective formylation of aromatic C-H bonds is of great importance, since aromatic aldehydes are valuable synthetic intermediates in organic chemistry. Recently, an impressive progress has been made in this field. However, an effective strategy for the selective formylation of N,N-substituted anilines is still needed. In this regard, we disclose a novel oxidant-induced para-selective formylation of N,N-substituted aniline towards the synthesis of aromatic aldehydes in this work. Using DDQ as the sole oxidant, various N,N-substituted anilines could be transformed into the desired formylation products under metal-free conditions, and the yield is up to 92%.
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