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The immune contexture in human tumours: impact on clinical outcome

Journal

NATURE REVIEWS CANCER
Volume 12, Issue 4, Pages 298-306

Publisher

NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3245

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Funding

  1. National Cancer Institute (INCa) [07/3D1616, PLBio2009-07, PLBio2010]
  2. Canceropole Ile de France [R09194DD]
  3. Ville de Paris
  4. Association pour la Recherche sur le Cancer (ARC) [07/3D1616, PEMT, 3,185]
  5. ARC
  6. Fondation de France
  7. INSERM
  8. Universite Pierre et Marie Curie
  9. Universite Paris Descartes
  10. Qatar-Foundation NPRP [09-1174-3-291]
  11. European Commission [202,230]
  12. LabEx Immuno-Oncology

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Tumours grow within an intricate network of epithelial cells, vascular and lymphatic vessels, cytokines and chemokines, and infiltrating immune cells. Different types of infiltrating immune cells have different effects on tumour progression, which can vary according to cancer type. In this Opinion article we discuss how the context-specific nature of infiltrating immune cells can affect the prognosis of patients.

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