Fluorescently Labeled Single-Walled Carbon Nanotubes and Their Hybrids with Oligonucleotides

The approach to the preparation of fluorescein-labeled single-walled carbon nanotubes was proposed. The investigation of physico-chemical properties of obtained modified nanotubes was performed. The method of the design of non-covalent hybrids of fluorescein-labeled carbon nanotubes with nucleic acid fragments containing pyrene residues at 5'-termini was developed. This method is based on stacking interactions of pyrene residues with carbon nanotubes surface. The effect of carbon nanotubes functionalization type on the efficacy of sorption of pyrene conjugates of oligonucleotides was examined.