The prognostic role of serum uric acid level in patients with acute ST elevation myocardial infarction

Objectives: The role of uric acid as a prognostic factor in patients with acute ST elevation myocardial infarction is controversial. The purpose of this study was to demonstrate the relationship between serum uric acid level and mortality during admission period and 30-day period after admission. Methods: We assessed the relation between serum uric acid level and in-hospital and short-term mortality rates in 184 patients admitted with acute ST elevation myocardial infarction. We divided the patients according to their gender and uric acid level measured on admission into four groups: group A(1): men with uric acid <= 7 mg/dl versus group B-1: men with uric acid >7 mg/dl and group A(2): women with uric acid <= 5.6 mg/dl versus group B-2: women with uric acid >5.6 mg/dl. The patients were followed for 30 days after admission. Results: In-hospital mortality rate in group B-1 was higher than group A(1) [P value: 0.011, Relative risk: 13.33 (95% confidence interval: 1.55-114.7)]. Short-term all-cause mortality was significantly higher in group B-1 patients [P value: 0.037, Relative risk: 3.3 (95% confidence interval: 1.02-10.64)]. Multivariate logistic regression analysis of data showed an odds ratio of 15.23 for in-hospital mortality and odds ratio of 3.76 for short-term mortality in male hyperuricemic patients. Conclusions: Our data suggest that in the acute phase of ST elevation myocardial infarction, uric acid has a prognostic role for in-hospital and short-term (30-day) mortality in men. (C) 2012 King Saud University. Production and hosting by Elsevier B.V. All rights reserved.