Journal
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
Volume 6, Issue 6, Pages 8034-8039Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acssuschemeng.8b01531
Keywords
Sustainable chemistry; Green solvent; Peptide; Automatic synthesis
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Funding
- National Research Foundation (NRF) (CSUR Grant) [105892]
- National Research Foundation (NRF) (Blue Sky's Research Programme) [110960]
- University of KwaZulu-Natal (South Africa)
- Spanish Ministry of Economy, Industry and Competitiveness (MINECO) [CTQ2015-67870-P]
- Generalitat de Catalunya (Spain) [2017 SGR 1439]
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The increasing demand for synthetic peptides in various research fields raises a challenge, namely, the development of greener methods for their preparation. Here we report on an ecofriendly solid-phase peptide synthesis (SPPS) methodology. Substitution of the hazardous solvent DMF by the biomass-derived organic solvent y-valerolactone (GVL), together with the application of microwave-assisted automated SPPS, allowed the synthesis of peptides with a wide range of lengths and high purity using polystyrene- and polyethylene-glycol-based resins. The yields achieved were comparable to those obtained with standard methodologies. To date, this is the greenest approach reported in terms of the solvent used, waste generated, and energy efficiency.
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