Related references
Note: Only part of the references are listed.Nonsense-mediated mRNA Decay and Cancer
Maximilian W. Popp et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2018)
Targeting splicing abnormalities in cancer
Anant A. Agrawal et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2018)
Physiological Srsf2 P95H expression causes impaired hematopoietic stem cell functions and aberrant RNA splicing in mice
Ayana Kon et al.
BLOOD (2018)
Autogenous cross-regulation of Quaking mRNA processing and translation balances Quaking functions in splicing and translation
W. Samuel Fagg et al.
GENES & DEVELOPMENT (2017)
Chemotherapy induces alternative transcription and splicing: Facts and hopes for cancer treatment
Charles A. Lambert et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2017)
Fyn/heterogeneous nuclear ribonucleoprotein E1 signaling regulates pancreatic cancer metastasis by affecting the alternative splicing of integrin β1
Peng Jiang et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2017)
Isoform switch of CD44 induces different chemotactic and tumorigenic ability in gallbladder cancer
Takeshi Miwa et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2017)
The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes
Bon Ham Yip et al.
JOURNAL OF CLINICAL INVESTIGATION (2017)
Body Temperature Cycles Control Rhythmic Alternative Splicing in Mammals
Marco Preussner et al.
MOLECULAR CELL (2017)
Cellular uptake and trafficking of antisense oligonucleotides
Stanley T. Crooke et al.
NATURE BIOTECHNOLOGY (2017)
Selective degradation of splicing factor CAPERα by anticancer sulfonamides
Taisuke Uehara et al.
NATURE CHEMICAL BIOLOGY (2017)
hnRNPM guides an alternative splicing program in response to inhibition of the PI3K/AKT/mTOR pathway in Ewing sarcoma cells
Ilaria Passacantilli et al.
NUCLEIC ACIDS RESEARCH (2017)
Pyruvate kinase M2 is a poor prognostic marker of and a therapeutic target in ovarian cancer
Tai-Kuang Chao et al.
PLOS ONE (2017)
Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15
Ting Han et al.
SCIENCE (2017)
Pyruvate kinase M2 deregulation enhances the metastatic potential of tongue squamous cell carcinoma
Wei Wang et al.
Oncotarget (2017)
microRNA-451-modulated hnRNP A1 takes a part in granulocytic differentiation regulation and acute myeloid leukemia
Li Song et al.
ONCOTARGET (2017)
Functional analysis reveals that RBM10 mutations contribute to lung adenocarcinoma pathogenesis by deregulating splicing
Jiawei Zhao et al.
SCIENTIFIC REPORTS (2017)
The Functional Impact of Alternative Splicing in Cancer
Hector Climente-Gonzalez et al.
CELL REPORTS (2017)
Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability
Brenton R. Paolella et al.
ELIFE (2017)
Induced-Decay of Glycine Decarboxylase Transcripts as an Anticancer Therapeutic Strategy for Non-Small-Cell Lung Carcinoma
Jing Lin et al.
MOLECULAR THERAPY-NUCLEIC ACIDS (2017)
RAC1b overexpression stimulates proliferation and NF-κB-mediated anti-apoptotic signaling in thyroid cancer cells
Marcia Faria et al.
PLOS ONE (2017)
Splicing factor SF3B1K700E mutant dysregulates erythroid differentiation via aberrant alternative splicing of transcription factor TAL1
Shuiling Jin et al.
PLOS ONE (2017)
Prognostic value of SRSF2 mutations in patients with de novo myelodysplastic syndromes: A meta-analysis
Xue Zheng et al.
PLOS ONE (2017)
CD44v8-10 as a potential theranostic biomarker for targeting disseminated cancer cells in advanced gastric cancer
Eun-Seok Choi et al.
SCIENTIFIC REPORTS (2017)
Snail Driving Alternative Splicing of CD44 by ESRP1 Enhances Invasion and Migration in Epithelial Ovarian Cancer
Le Chen et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2017)
PKM2 is not required for colon cancer initiated by APC loss
Allison N. Lau et al.
CANCER & METABOLISM (2017)
Splice variants of the extracellular region of RON receptor tyrosine kinase in lung cancer cell lines identified by PCR and sequencing
Soundararajan Krishnaswamy et al.
BMC CANCER (2017)
Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of MED12 and RBM10 as Novel Thyroid Cancer Genes Associated with Tumor Virulence
Tihana Ibrahimpasic et al.
CLINICAL CANCER RESEARCH (2017)
Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma
A. Gordon Robertson et al.
CANCER CELL (2017)
Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation
Karl Bertram et al.
CELL (2017)
Splicing-Correcting Therapy for SMA
Lili Wan et al.
CELL (2017)
The role of TGF-β and its crosstalk with RAC1/RAC1b signaling in breast and pancreas carcinoma
Catharina Melzer et al.
CELL COMMUNICATION AND SIGNALING (2017)
Enhanced expression of the M2 isoform of pyruvate kinase is involved in gastric cancer development by regulating cancer-specific metabolism
Takeharu Shiroki et al.
CANCER SCIENCE (2017)
An Atomic Structure of the Human Spliceosome
Xiaofeng Zhang et al.
CELL (2017)
Knockdown of hnRNPK leads to increased DNA damage after irradiation and reduces survival of tumor cells
Nadine Wiesmann et al.
CARCINOGENESIS (2017)
Characterization of the expression of the pro-metastatic MenaINV isoform during breast tumor progression
Madeleine J. Oudin et al.
CLINICAL & EXPERIMENTAL METASTASIS (2016)
Relative expression of vascular endothelial growth factor isoforms in squamous cell carcinoma of the head and neck
Mark D. Wilkie et al.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2016)
Antisense oligonucleotide-mediated MDM4 exon 6 skipping impairs tumor growth
Michael Dewaele et al.
JOURNAL OF CLINICAL INVESTIGATION (2016)
Modulation of PKM alternative splicing by PTBP1 promotes gemcitabine resistance in pancreatic cancer cells
S. Calabretta et al.
ONCOGENE (2016)
Pro-apoptotic effects of splice-switching oligonucleotides targeting Bcl-x pre-mRNA in human glioma cell lines
Zhaohui Li et al.
ONCOLOGY REPORTS (2016)
Harnessing RNAi-based nanomedicines for therapeutic gene silencing in B-cell malignancies
Shiri Weinstein et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Expression of the FGFR2 mesenchymal splicing variant in epithelial cells drives epithelial-mesenchymal transition
Danilo Ranieri et al.
ONCOTARGET (2016)
Physiologic Expression of Sf3b1K700E Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation
Esther A. Obeng et al.
CANCER CELL (2016)
Irreversible inhibition of Δ16HER2 is necessary to suppress Δ16HER2-positive breast carcinomas resistant to Lapatinib
Martina Tilio et al.
CANCER LETTERS (2016)
MYCN controls an alternative RNA splicing program in high-risk metastatic neuroblastoma
Shile Zhang et al.
CANCER LETTERS (2016)
Long non-coding RNA LINC01133 inhibits epithelial-mesenchymal transition and metastasis in colorectal cancer by interacting with SRSF6
Jianlu Kong et al.
CANCER LETTERS (2016)
The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin
Yifan Wang et al.
CANCER RESEARCH (2016)
The Basis of Oncoimmunology
A. Karolina Palucka et al.
CELL (2016)
Identification of TRA2B-DNAH5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma
Fei Li et al.
CELL RESEARCH (2016)
PKM2, cancer metabolism, and the road ahead
Talya L. Dayton et al.
EMBO REPORTS (2016)
Knockdown of HNRNPA1 inhibits lung adenocarcinoma cell proliferation through cell cycle arrest at G0/G1 phase
Xianxun Liu et al.
GENE (2016)
microRNAs target SRSF7 splicing factor to modulate the expression of osteopontin splice variants in renal cancer cells
Joanna Boguslawska et al.
GENE (2016)
High expression of Mcl-1L via the MEK-ERK-phospho-STAT3 (Ser727) pathway protects melanocytes and melanoma from UVB-induced apoptosis
Takeshi Fukumoto et al.
GENES TO CELLS (2016)
Large-scale analysis of genome and transcriptome alterations in multiple tumors unveils novel cancer-relevant splicing networks
Endre Sebestyen et al.
GENOME RESEARCH (2016)
The hnRNP family: insights into their role in health and disease
Thomas Geuens et al.
HUMAN GENETICS (2016)
Expression of SRSF3 is Correlated with Carcinogenesis and Progression of Oral Squamous Cell Carcinoma
Liu Peiqi et al.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2016)
SRSF5: a novel marker for small-cell lung cancer and pleural metastatic cancer
Hak-Ryul Kim et al.
LUNG CANCER (2016)
mRNA expression of delta-HER2 and its clinicopathological correlation in HER2-overexpressing breast cancer
Ryuichi Wada et al.
MOLECULAR MEDICINE REPORTS (2016)
A large-scale analysis of alternative splicing reveals a key role of QKI in lung cancer
Fernando J. de Miguel et al.
MOLECULAR ONCOLOGY (2016)
MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism
Pratiti Bandopadhayay et al.
NATURE GENETICS (2016)
Therapeutic targeting of splicing in cancer
Stanley Chun-Wei Lee et al.
NATURE MEDICINE (2016)
Results from a phase 1 study of nusinersen (ISIS-SMNRx) in children with spinal muscular atrophy
Claudia A. Chiriboga et al.
NEUROLOGY (2016)
Splice-switching antisense oligonucleotides as therapeutic drugs
Mallory A. Havens et al.
NUCLEIC ACIDS RESEARCH (2016)
The delivery of therapeutic oligonucleotides
Rudolph L. Juliano
NUCLEIC ACIDS RESEARCH (2016)
CD82 suppresses CD44 alternative splicing-dependent melanoma metastasis by mediating U2AF2 ubiquitination and degradation
P. Zhang et al.
ONCOGENE (2016)
The Involvement of Splicing Factor hnRNP A1 in UVB-induced Alternative Splicing of hdm2
Jianguo Feng et al.
PHOTOCHEMISTRY AND PHOTOBIOLOGY (2016)
CD44 Splice Variant v8-10 as a Marker of Serous Ovarian Cancer Prognosis
Amanda Sosulski et al.
PLOS ONE (2016)
Tumor suppressor properties of the splicing regulatory factor RBM10
Jordi Hernandez et al.
RNA BIOLOGY (2016)
Splicing-factor alterations in cancers
Olga Anczukow et al.
RNA (2016)
Small Molecule Modulators of Pre-mRNA Splicing in Cancer Therapy
Maayan Salton et al.
TRENDS IN MOLECULAR MEDICINE (2016)
Alternative splicing of S6K1 promotes non-small cell lung cancer survival
Hong Mei et al.
TUMOR BIOLOGY (2016)
Extending the Impact of RAC1b Overexpression to Follicular Thyroid Carcinomas
Marcia Faria et al.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (2016)
Regulation of alternative splicing of Bcl-x by BC200 contributes to breast cancer pathogenesis
R. Singh et al.
CELL DEATH & DISEASE (2016)
Akt-dependent activation of Erk by cyclin Dlb. contributes to cell invasiveness and tumorigenicity
Chul Jang Kim et al.
ONCOLOGY LETTERS (2016)
An extended U2AF65-RNA-binding domain recognizes the 3′ splice site signal
Anant A. Agrawa et al.
NATURE COMMUNICATIONS (2016)
Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage
Samar Alsafadi et al.
NATURE COMMUNICATIONS (2016)
Regulation of androgen receptor splice variant AR3 by PCGEM1
Ziqiang Zhang et al.
ONCOTARGET (2016)
Rac1b enhances cell survival through activation of the JNK2/c-JUN/Cyclin-D1 and AKT2/MCL1 pathways
Gang Li et al.
ONCOTARGET (2016)
The alternatively-included 11a sequence modifies the effects of Mena on actin cytoskeletal organization and cell behavior
Michele Balsamo et al.
SCIENTIFIC REPORTS (2016)
Elucidating Genomic Characteristics of Lung Cancer Progression from In Situ to Invasive Adenocarcinoma
Chanida Vinayanuwattikun et al.
SCIENTIFIC REPORTS (2016)
Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma (vol 15, pg 857, 2016)
Marios Giannakis et al.
CELL REPORTS (2016)
Genomic Landscape Survey Identifies SRSF1 as a Key Oncodriver in Small Cell Lung Cancer
Liyan Jiang et al.
PLOS GENETICS (2016)
Expression of an Oncogenic BARD1 Splice Variant Impairs Homologous Recombination and Predicts Response to PARP-1 Inhibitor Therapy in Colon Cancer
Ozkan Ozden et al.
SCIENTIFIC REPORTS (2016)
Association of BIM Deletion Polymorphism and BIM-γ RNA Expression in NSCLC with EGFR Mutation
Kazutoshi Isobe et al.
CANCER GENOMICS & PROTEOMICS (2016)
MiR-30a-5p is induced by Wnt/β-catenin pathway and promotes glioma cell invasion by repressing NCAM
Zhongyong Wang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)
Heterogeneous nuclear ribonucleoprotein A1 post-transcriptionally regulates Drp1 expression in neuroblastoma cells
So Jung Park et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2015)
hnRNP L inhibits CD44 V10 exon splicing through interacting with its upstream intron
Tiing Jen Loh et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2015)
Dual role of CD44 isoforms in ampullary adenocarcinoma: CD44s predicts poor prognosis in early cancer and CD44. is an indicator for recurrence in advanced cancer
Cheng-Lin Wu et al.
BMC CANCER (2015)
HNRNP G and HTRA2-BETA1 regulate estrogen receptor alpha expression with potential impact on endometrial cancer
Marc Hirschfeld et al.
BMC CANCER (2015)
Role of the splicing factor SRSF4 in cisplatin-induced modifications of pre-mRNA splicing and apoptosis
Maude Gabriel et al.
BMC CANCER (2015)
SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition
Eunhee Kim et al.
CANCER CELL (2015)
hnRNP K Is a Haploinsufficient Tumor Suppressor that Regulates Proliferation and Differentiation Programs in Hematologic Malignancies
Miguel Gallardo et al.
CANCER CELL (2015)
CLK2 Is an Oncogenic Kinase and Splicing Regulator in Breast Cancer
Taku Yoshida et al.
CANCER RESEARCH (2015)
SnapShot: Spliceosome Dynamics I
Markus C. Wahl et al.
CELL (2015)
Detained introns are a novel, widespread class of post-transcriptionally spliced introns
Paul L. Boutz et al.
GENES & DEVELOPMENT (2015)
A laminin 511 matrix is regulated by TAZ and functions as the ligand for the α6Bβ1 integrin to sustain breast cancer stem cells
Cheng Chang et al.
GENES & DEVELOPMENT (2015)
Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B
Manoj K. Kashyap et al.
HAEMATOLOGICA (2015)
B Cell-Intrinsic Expression of the HuR RNA-Binding Protein Is Required for the T Cell-Dependent Immune Response In Vivo
Amy DeMicco et al.
JOURNAL OF IMMUNOLOGY (2015)
Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells (vol 29, pg 1092, 2015)
H. Dolatshad et al.
LEUKEMIA (2015)
Pyruvate kinase isoform M2 (PKM2) participates in multiple myeloma cell proliferation, adhesion and chemoresistance
Yunhua He et al.
LEUKEMIA RESEARCH (2015)
SRSF2 Is Essential for Hematopoiesis, and Its Myelodysplastic Syndrome-Related Mutations Dysregulate Alternative Pre-mRNA Splicing
Yukiko Komeno et al.
MOLECULAR AND CELLULAR BIOLOGY (2015)
Serine/arginine-rich splicing factor 3 (SRSF3) regulates homologous recombination-mediated DNA repair
Xiaolong He et al.
MOLECULAR CANCER (2015)
Significance of Polypyrimidine Tract-Binding Protein 1 Expression in Colorectal Cancer
Hidekazu Takahashi et al.
MOLECULAR CANCER THERAPEUTICS (2015)
SRSF1-Regulated Alternative Splicing in Breast Cancer
Olga Anczukow et al.
MOLECULAR CELL (2015)
Genome-Wide Identification of Fas/CD95 Alternative Splicing Regulators Reveals Links with Iron Homeostasis
J. Ramon Tejedor et al.
MOLECULAR CELL (2015)
The spliceosome is a therapeutic vulnerability in MYC-driven cancer
Tiffany Y. -T. Hsu et al.
NATURE (2015)
MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis
Cheryl M. Koh et al.
NATURE (2015)
The RNA-binding protein HuR is essential for the B cell antibody response
Manuel D. Diaz-Munoz et al.
NATURE IMMUNOLOGY (2015)
Identification of recurrent regulated alternative splicing events across human solid tumors
Miri Danan-Gotthold et al.
NUCLEIC ACIDS RESEARCH (2015)
RON alternative splicing regulation in primary ovarian cancer
Sebastian Mayer et al.
ONCOLOGY REPORTS (2015)
Knocking down the expression of TRA2 beta inhibits the proliferation and migration of human glioma cells
Lixiang Yang et al.
PATHOLOGY RESEARCH AND PRACTICE (2015)
Splicing inhibition of U2AF65 leads to alternative exon skipping
Sunghee Cho et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Disease-associated mutation in SRSF2 misregulates splicing by altering RNA-binding affinities
Jian Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Tissue stiffness regulates serine/arginine-rich protein-mediated splicing of the extra domain B-fibronectin isoform in tumors
Francois Bordeleau et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
SRSF3 and hnRNP H1 regulate a splicing hotspot of HER2 in breast cancer cells
Hannah Gautrey et al.
RNA BIOLOGY (2015)
Prp40 pre-mRNA processing factor 40 homolog B (PRPF40B) associates with SF1 and U2AF65 and modulates alternative pre-mRNA splicing in vivo
Soraya Becerra et al.
RNA (2015)
AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer
David Hong et al.
SCIENCE TRANSLATIONAL MEDICINE (2015)
Pyruvate kinase: Function, regulation and role in cancer
William J. Israelsen et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2015)
Insights into the roles of hnRNP A2/B1 and AXL in non-small cell lung cancer
Xiao-Han Qu et al.
ONCOLOGY LETTERS (2015)
Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome
Vikas Madan et al.
NATURE COMMUNICATIONS (2015)
Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets
Agnieszka K. Witkiewicz et al.
NATURE COMMUNICATIONS (2015)
Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy
Elena Sotillo et al.
CANCER DISCOVERY (2015)
Tenascin C in metastasis: A view from the invasive front
Camille M. Lowy et al.
CELL ADHESION & MIGRATION (2015)
The splicing modulator sudemycin induces a specific antitumor response and cooperates with ibrutinib in chronic lymphocytic leukemia
Silvia Xargay-Torrent et al.
ONCOTARGET (2015)
Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3′ Splice Site Selection through Use of a Different Branch Point
Rachel B. Darman et al.
CELL REPORTS (2015)
SF3B1 Association with Chromatin Determines Splicing Outcomes
Nir Kfir et al.
CELL REPORTS (2015)
Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B
Manoj K. Kashyap et al.
HAEMATOLOGICA (2015)
SF3B1 mutations constitute a novel therapeutic target in breast cancer
Sarah L. Maguire et al.
JOURNAL OF PATHOLOGY (2015)
The impact of SF3B1 mutations in CLL on the DNA-damage response
G. D. te Raa et al.
LEUKEMIA (2015)
Serine-arginine protein kinase 1 (SRPK1) inhibition as a potential novel targeted therapeutic strategy in prostate cancer
A. Mavrou et al.
ONCOGENE (2015)
PKM2 promotes metastasis by recruiting myeloid-derived suppressor cells and indicates poor prognosis for hepatocellular carcinoma
Wei-Ren Liu et al.
ONCOTARGET (2015)
Exon 9 skipping of apoptotic caspase-2 pre-mRNA is promoted by SRSF3 through interaction with exon 8
Ha Na Jang et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2014)
The tumor suppressing effects of QKI-5 in prostate cancer A novel diagnostic and prognostic protein
Yi Zhao et al.
CANCER BIOLOGY & THERAPY (2014)
QKI impairs self-renewal and tumorigenicity of oral cancer cells via repression of SOX2
Wei Lu et al.
CANCER BIOLOGY & THERAPY (2014)
The Splicing Factor RBM4 Controls Apoptosis, Proliferation, and Migration to Suppress Tumor Progression
Yang Wang et al.
CANCER CELL (2014)
Cyclin D1b splice variant promotes αvβ3-mediated adhesion and invasive migration of breast cancer cells
Feng-Hua Wu et al.
CANCER LETTERS (2014)
CD44v8-10 Is a Cancer-Specific Marker for Gastric Cancer Stem Cells
Wen Min Lau et al.
CANCER RESEARCH (2014)
Activated d16HER2 Homodimers and SRC Kinase Mediate Optimal Efficacy for Trastuzumab
Lorenzo Castagnoli et al.
CANCER RESEARCH (2014)
Building Robust Transcriptomes with Master Splicing Factors
Mohini Jangi et al.
CELL (2014)
The transcription factor FBI-1 inhibits SAM68-mediated BCL-X alternative splicing and apoptosis
Pamela Bielli et al.
EMBO REPORTS (2014)
Stem-loop 4 of U1 snRNA is essential for splicing and interacts with the U2 snRNP-specific SF3A1 protein during spliceosome assembly
Shalini Sharma et al.
GENES & DEVELOPMENT (2014)
Rbfox2 controls autoregulation in RNA-binding protein networks
Mohini Jangi et al.
GENES & DEVELOPMENT (2014)
Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing
Yilin Xu et al.
GENES & DEVELOPMENT (2014)
Comparative Genomics RNAi Screen Identifies Eftud2 as a Novel Regulator of Innate Immunity
Lesly De Arras et al.
GENETICS (2014)
Relative expression of hMena11a and hMenaINV splice isoforms is a useful biomarker in development and progression of human breast carcinoma
Noriyuki Tanaka et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2014)
Epithelial Splicing Regulatory Proteins 1 (ESRP1) and 2 (ESRP2) Suppress Cancer Cell Motility via Different Mechanisms
Hiroki Ishii et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Isoforms of Receptors of Fibroblast Growth Factors
Siew-Ging Gong
JOURNAL OF CELLULAR PHYSIOLOGY (2014)
Transformer 2β (Tra2β/SFRS10) positively regulates the progression of NSCLC via promoting cell proliferation
Lili Ji et al.
JOURNAL OF MOLECULAR HISTOLOGY (2014)
Emerging Functions of SRSF1, Splicing Factor and Oncoprotein, in RNA Metabolism and Cancer
Shipra Das et al.
MOLECULAR CANCER RESEARCH (2014)
Comprehensive molecular profiling of lung adenocarcinoma
Eric A. Collisson et al.
NATURE (2014)
Splicing factor SRSF6 promotes hyperplasia of sensitized skin
Mads A. Jensen et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2014)
Rare SF3B1 R625 mutations in cutaneous melanoma
Yong Kong et al.
MELANOMA RESEARCH (2014)
Redirecting splicing with bifunctional oligonucleotides
Jean-Philippe Brosseau et al.
NUCLEIC ACIDS RESEARCH (2014)
Regulation of BCL-X splicing reveals a role for the polypyrimidine tract binding protein (PTBP1/hnRNP I) in alternative 5′ splice site selection
Pamela Bielli et al.
NUCLEIC ACIDS RESEARCH (2014)
Sudemycin E influences alternative splicing and changes chromatin modifications
Paolo Convertini et al.
NUCLEIC ACIDS RESEARCH (2014)
SC35 promotes splicing of the C5-V6-C6 isoform of CD44 pre-mRNA
Tiing Jen Loh et al.
ONCOLOGY REPORTS (2014)
Neuronal-Specific Deficiency of the Splicing Factor Tra2b Causes Apoptosis in Neurogenic Areas of the Developing Mouse Brain
Markus Storbeck et al.
PLOS ONE (2014)
Identification of cis-Acting Elements and Splicing Factors Involved in the Regulation of BIM Pre-mRNA Splicing
Wen Chun Juan et al.
PLOS ONE (2014)
Overexpression of Mcl-1L Splice Variant Is Associated with Poor Prognosis and Chemoresistance in Oral Cancers
Vinayak Palve et al.
PLOS ONE (2014)
MicroRNA-7 Inhibits Multiple Oncogenic Pathways to Suppress HER2Δ16 Mediated Breast Tumorigenesis and Reverse Trastuzumab Resistance
Felicia C. Huynh et al.
PLOS ONE (2014)
Phosphorylation of SRSF1 by SRPK1 regulates alternative splicing of tumor-related Rac1b in colorectal cells
Vania Goncalves et al.
RNA (2014)
The alternative splicing side of cancer
Giuseppe Biamonti et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2014)
Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation
Goro Sashida et al.
NATURE COMMUNICATIONS (2014)
Prognostic impact of alternative splicing-derived hMENA isoforms in resected, node-negative, non-small-cell lung cancer
Emilio Bria et al.
ONCOTARGET (2014)
Regulation of FAS Exon Definition and Apoptosis by the Ewing Sarcoma Protein
Maria Paola Paronetto et al.
CELL REPORTS (2014)
Regulated Splicing of the α6 Integrin Cytoplasmic Domain Determines the Fate of Breast Cancer Stem Cells
Hira Lal Goel et al.
CELL REPORTS (2014)
Mnk2 Alternative Splicing Modulates the p38-MAPK Pathway and Impacts Ras-Induced Transformation
Avraham Maimon et al.
CELL REPORTS (2014)
The RNA-Binding Protein QKI Suppresses Cancer-Associated Aberrant Splicing
Feng-Yang Zong et al.
PLOS GENETICS (2014)
Splicing factor mutations and cancer
Kenichi Yoshida et al.
WILEY INTERDISCIPLINARY REVIEWS-RNA (2014)
hnRNP A1 contacts exon 5 to promote exon 6 inclusion of apoptotic Fas gene
Hyun Kyung Oh et al.
APOPTOSIS (2013)
Directing HER4 mRNA expression towards the CYT2 isoform by antisense oligonucleotide decreases growth of breast cancer cells in vitro and in vivo
T. O. Nielsen et al.
BRITISH JOURNAL OF CANCER (2013)
Mammary Tumor Formation and Metastasis Evoked by a HER2 Splice Variant
Abdullah Alajati et al.
CANCER RESEARCH (2013)
PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells
William J. Israelsen et al.
CELL (2013)
Tumor-Specific Isoform Switch of the Fibroblast Growth Factor Receptor 2 Underlies the Mesenchymal and Malignant Phenotypes of Clear Cell Renal Cell Carcinomas
Qi Zhao et al.
CLINICAL CANCER RESEARCH (2013)
Control of alternative splicing in immune responses: many regulators, many predictions, much still to learn
Nicole M. Martinez et al.
IMMUNOLOGICAL REVIEWS (2013)
Overexpression of HnRNP A1 promotes tumor invasion through regulating CD44v6 and indicates poor prognosis for hepatocellular carcinoma
Zheng-Jun Zhou et al.
INTERNATIONAL JOURNAL OF CANCER (2013)
Alterations in Expression Pattern of Splicing Factors in Epithelial Ovarian Cancer and its Clinical Impact
Severine Iborra et al.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2013)
Heterogeneous Nuclear Ribonucleoprotein K (hnRNP-K) Promotes Tumor Metastasis by Induction of Genes Involved in Extracellular Matrix, Cell Movement, and Angiogenesis
Ran Gao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Convergence of oncogenic and hormone receptor pathways promotes metastatic phenotypes
Michael A. Augello et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Ets1 and heat shock factor 1 regulate transcription of the Transformer 2β gene in human colon cancer cells
Keisuke Kajita et al.
JOURNAL OF GASTROENTEROLOGY (2013)
The splicing factor SRSF6 is amplified and is an oncoprotein inlung and colon cancers
Michal Cohen-Eliav et al.
JOURNAL OF PATHOLOGY (2013)
RBFOX2 Is an Important Regulator of Mesenchymal Tissue-Specific Splicing in both Normal and Cancer Tissues
Julian P. Venables et al.
MOLECULAR AND CELLULAR BIOLOGY (2013)
RBM5, 6, and 10 Differentially Regulate NUMB Alternative Splicing to Control Cancer Cell Proliferation
Elias G. Bechara et al.
MOLECULAR CELL (2013)
Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells
Alex K. Shalek et al.
NATURE (2013)
Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3
Marcel Martin et al.
NATURE GENETICS (2013)
Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma
J. William Harbour et al.
NATURE GENETICS (2013)
Microenvironmental regulation of tumor progression and metastasis
Daniela F. Quail et al.
NATURE MEDICINE (2013)
The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis
C. Zhou et al.
ONCOGENE (2013)
Downregulation of splicing factor SRSF3 induces p53β, an alternatively spliced isoform of p53 that promotes cellular senescence
Y. Tang et al.
ONCOGENE (2013)
Requirement of Heterogeneous Nuclear Ribonucleoprotein C for BRCA Gene Expression and Homologous Recombination
Rachel W. Anantha et al.
PLOS ONE (2013)
Caspase-2 Short Isoform Interacts with Membrane-Associated Cytoskeleton Proteins to Inhibit Apoptosis
Chunhua Han et al.
PLOS ONE (2013)
MCL-1ES Induces MCL-1L-Dependent BAX- and BAK-Independent Mitochondrial Apoptosis
Jae-Hong Kim et al.
PLOS ONE (2013)
M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth
Marta Cortes-Cros et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Differential splicing across immune system lineages
Ayla Ergun et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
KLF6-SV1 Drives Breast Cancer Metastasis and Is Associated with Poor Survival
Raheleh Hatami et al.
SCIENCE TRANSLATIONAL MEDICINE (2013)
S6K1 Alternative Splicing Modulates Its Oncogenic Activity and Regulates mTORC1
Vered Ben-Hur et al.
CELL REPORTS (2013)
The significant other: splicing by the minor spliceosome
Janne J. Turunen et al.
WILEY INTERDISCIPLINARY REVIEWS-RNA (2013)
KLF6 Loss of Function in Human Prostate Cancer Progression Is Implicated in Resistance to Androgen Deprivation
XiaoMei Liu et al.
AMERICAN JOURNAL OF PATHOLOGY (2012)
Enhanced Expression of Fibroblast Growth Factor Receptor 2 IIIc Promotes Human Pancreatic Cancer Cell Proliferation
Toshiyuki Ishiwata et al.
AMERICAN JOURNAL OF PATHOLOGY (2012)
SRSF2 mutations in 275 cases with chronic myelomonocytic leukemia (CMML)
Manja Meggendorfer et al.
BLOOD (2012)
Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing
Marcin Imielinski et al.
CELL (2012)
BRCA2 Deep Intronic Mutation Causing Activation of a Cryptic Exon: Opening toward a New Preventive Therapeutic Strategy
Olga Anczukow et al.
CLINICAL CANCER RESEARCH (2012)
SRp20 is a proto-oncogene critical for cell proliferation and tumor induction and maintenance
Rong Jia et al.
International Journal of Biological Sciences (2012)
Extra-domain B in Oncofetal Fibronectin Structurally Promotes Fibrillar Head-to-tail Dimerization of Extracellular Matrix Protein
Andre Schiefner et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
The extracellular matrix: A dynamic niche in cancer progression
Pengfei Lu et al.
JOURNAL OF CELL BIOLOGY (2012)
Loss of Pnn expression results in mouse early embryonic lethality and cellular apoptosis through SRSF1-mediated alternative expression of Bcl-xS and ICAD
Steve Leu et al.
JOURNAL OF CELL SCIENCE (2012)
Involvement of hnRNP A1 in the Matrix Metalloprotease-3-Dependent Regulation of Rac1 Pre-mRNA Splicing
Federico Pelisch et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2012)
Genome-Wide Determination of a Broad ESRP-Regulated Posttranscriptional Network by High-Throughput Sequencing
Kimberly A. Dittmar et al.
MOLECULAR AND CELLULAR BIOLOGY (2012)
Fibroblast Growth Factor Receptor 2 IIIc as a Therapeutic Target for Colorectal Cancer Cells
Yoko Matsuda et al.
MOLECULAR CANCER THERAPEUTICS (2012)
PTBP1-Dependent Regulation of USP5 Alternative RNA Splicing Plays a Role in Glioblastoma Tumorigenesis
Daisy I. Izaguirre et al.
MOLECULAR CARCINOGENESIS (2012)
Dynamic Protein-Protein Interaction Wiring of the Human Spliceosome
Anna Hegele et al.
MOLECULAR CELL (2012)
The Akt-SRPK-SR Axis Constitutes a Major Pathway in Transducing EGF Signaling to Regulate Alternative Splicing in the Nucleus
Zhihong Zhou et al.
MOLECULAR CELL (2012)
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
Andrew V. Biankin et al.
NATURE (2012)
Synthetic oligonucleotides recruit ILF2/3 to RNA transcripts to modulate splicing
Frank Rigo et al.
NATURE CHEMICAL BIOLOGY (2012)
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
Dimitrios Anastasiou et al.
NATURE CHEMICAL BIOLOGY (2012)
Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia
Victor Quesada et al.
NATURE GENETICS (2012)
A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer
King Pan Ng et al.
NATURE MEDICINE (2012)
The spliceosome as a target of novel antitumour drugs
Sophie Bonnal et al.
NATURE REVIEWS DRUG DISCOVERY (2012)
RNA therapeutics: beyond RNA interference and antisense oligonucleotides
Ryszard Kole et al.
NATURE REVIEWS DRUG DISCOVERY (2012)
The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation
Olga Anczukow et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)
Evidence for upregulation of Bim and the splicing factor SRp55 in melanoma cells from patients treated with selective BRAF inhibitors
Fritz Lai et al.
MELANOMA RESEARCH (2012)
HnRNP L and L-like cooperate in multiple-exon regulation of CD45 alternative splicing
Marco Preussner et al.
NUCLEIC ACIDS RESEARCH (2012)
TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP
K. Horiguchi et al.
ONCOGENE (2012)
CD28 Costimulation Regulates Genome-Wide Effects on Alternative Splicing
Manish J. Butte et al.
PLOS ONE (2012)
Elevated Expression of the Serine-Arginine Protein Kinase 1 Gene in Ovarian Cancer and Its Role in Cisplatin Cytotoxicity In Vitro
Kunle Odunsi et al.
PLOS ONE (2012)
Regulation of Mcl-1 by SRSF1 and SRSF5 in Cancer Cells
Hannah L. Gautrey et al.
PLOS ONE (2012)
Association of anti-apoptotic Mcl-1L isoform expression with radioresistance of oral squamous carcinoma cells
Vinayak C. Palve et al.
RADIATION ONCOLOGY (2012)
Splicing program of human MENA produces a previously undescribed isoform associated with invasive, mesenchymal-like breast tumors
Francesca Di Modugno et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Protein cross-talk in CD133+colon cancer cells indicates activation of the Wnt pathway and upregulation of SRp20 that is potentially involved in tumorigenicity
Claudia Corbo et al.
PROTEOMICS (2012)
Alternative splicing networks regulated by signaling in human T cells
Nicole M. Martinez et al.
RNA (2012)
Exon-centric regulation of pyruvate kinase M alternative splicing via mutually exclusive exons
Zhenxun Wang et al.
JOURNAL OF MOLECULAR CELL BIOLOGY (2012)
Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell
Toshifumi Yae et al.
NATURE COMMUNICATIONS (2012)
Oncogenic Splicing Factor SRSF1 Is a Critical Transcriptional Target of MYC
Shipra Das et al.
CELL REPORTS (2012)
Manipulation of PK-M mutually exclusive alternative splicing by antisense oligonucleotides
Zhenxun Wang et al.
OPEN BIOLOGY (2012)
Sudemycins, Novel Small Molecule Analogues of FR901464, Induce Alternative Gene Splicing
Liying Fan et al.
ACS CHEMICAL BIOLOGY (2011)
Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms
Luca Malcovati et al.
BLOOD (2011)
Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness
Davide Rossi et al.
BLOOD (2011)
Splicing Factor hnRNP A2/B1 Regulates Tumor Suppressor Gene Splicing and Is an Oncogenic Driver in Glioblastoma
Regina Golan-Gerstl et al.
CANCER RESEARCH (2011)
Knocking down cyclin D1b inhibits breast cancer cell growth and suppresses tumor development in a breast cancer model
Min Wei et al.
CANCER SCIENCE (2011)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas
Clare V. LeFave et al.
EMBO JOURNAL (2011)
Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A
Anna Corrionero et al.
GENES & DEVELOPMENT (2011)
MicroRNAs-10a and-10b Contribute to Retinoic Acid-induced Differentiation of Neuroblastoma Cells and Target the Alternative Splicing Regulatory Factor SFRS1 (SF2/ASF)
Salvador Meseguer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression
Rhonda L. Brown et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
Poulikos I. Poulikakos et al.
NATURE (2011)
Frequent pathway mutations of splicing machinery in myelodysplasia
Kenichi Yoshida et al.
NATURE (2011)
Somatic SF3B1 Mutation in Myelodysplasia with Ring Sideroblasts
E. Papaemmanuil et al.
NEW ENGLAND JOURNAL OF MEDICINE (2011)
SF3B1 and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia
Lili Wang et al.
NEW ENGLAND JOURNAL OF MEDICINE (2011)
Antitumorigenic potential of STAT3 alternative splicing modulation
Francesca Zammarchi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
BIM Expression in Treatment-Naive Cancers Predicts Responsiveness to Kinase Inhibitors
Anthony C. Faber et al.
CANCER DISCOVERY (2011)
Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas
Toru Furukawa et al.
SCIENTIFIC REPORTS (2011)
An EMT-Driven Alternative Splicing Program Occurs in Human Breast Cancer and Modulates Cellular Phenotype
Irina M. Shapiro et al.
PLOS GENETICS (2011)
Massively Parallel Sequencing of Exons on the X Chromosome Identifies RBM10 as the Gene that Causes a Syndromic Form of Cleft Palate
Jennifer J. Johnston et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2010)
RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform
C. Frank Bennett et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (2010)
Modulation of mdm2 pre-mRNA splicing by 9-aminoacridine-PNA (peptide nucleic acid) conjugates targeting intron-exon junctions
Takehiko Shiraishi et al.
BMC CANCER (2010)
Expression proteomics of UPF1 knockdown in HeLa cells reveals autoregulation of hnRNP A2/B1 mediated by alternative splicing resulting in nonsense-mediated mRNA decay
Nicholas J. McGlincy et al.
BMC GENOMICS (2010)
Fibroblast growth factor receptor 3-IIIc mediates colorectal cancer growth and migration
G. Sonvilla et al.
BRITISH JOURNAL OF CANCER (2010)
Genome-wide Analysis of Novel Splice Variants Induced by Topoisomerase I Poisoning Shows Preferential Occurrence in Genes Encoding Splicing Factors
Stephanie Solier et al.
CANCER RESEARCH (2010)
Breast Cancer Cells in Three-dimensional Culture Display an Enhanced Radioresponse after Coordinate Targeting of Integrin α5β1 and Fibronectin
Jin-Min Nam et al.
CANCER RESEARCH (2010)
Oncogenic HER2δ16 suppresses miR-15a/16 and deregulates BCL-2 to promote endocrine resistance of breast tumors
Diana M. Cittelly et al.
CARCINOGENESIS (2010)
An Alternative Splicing Network Links Cell-Cycle Control to Apoptosis
Michael J. Moore et al.
CELL (2010)
The Oncoprotein SF2/ASF Promotes Non-Small Cell Lung Cancer Survival by Enhancing Survivin Expression
Teresa Ezponda et al.
CLINICAL CANCER RESEARCH (2010)
An ESRP-regulated splicing programme is abrogated during the epithelial-mesenchymal transition
Claude C. Warzecha et al.
EMBO JOURNAL (2010)
The U2AF35-related protein Urp contacts the 3′ splice site to promote U12-type intron splicing and the second step of U2-type intron splicing
Haihong Shen et al.
GENES & DEVELOPMENT (2010)
Deficiency of the splicing factor Sfrs10 results in early embryonic lethality in mice and has no impact on full-length SMN/Smn splicing
Ylva Mende et al.
HUMAN MOLECULAR GENETICS (2010)
Increased expression of the heterogeneous nuclear ribonucleoprotein K in pancreatic cancer and its association with the mutant p53
Renyuan Zhou et al.
INTERNATIONAL JOURNAL OF CANCER (2010)
Regulation of Vascular Endothelial Growth Factor (VEGF) Splicing from Pro-angiogenic to Anti-angiogenic Isoforms A NOVEL THERAPEUTIC STRATEGY FOR ANGIOGENESIS
Dawid G. Nowak et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
MicroRNA (miRNA)-mediated Interaction between Leukemia/Lymphoma-related Factor (LRF) and Alternative Splicing Factor/Splicing Factor 2 (ASF/SF2) Affects Mouse Embryonic Fibroblast Senescence and Apoptosis
Lorena Verduci et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
RBM5 as a Putative Tumor Suppressor Gene for Lung Cancer
Leslie C. Sutherland et al.
JOURNAL OF THORACIC ONCOLOGY (2010)
Exon-Level Microarray Analyses Identify Alternative Splicing Programs in Breast Cancer
Anna Lapuk et al.
MOLECULAR CANCER RESEARCH (2010)
The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation
Vidisha Tripathi et al.
MOLECULAR CELL (2010)
HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
Charles J. David et al.
NATURE (2010)
SF2/ASF autoregulation involves multiple layers of post-transcriptional and translational control
Shuying Sun et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)
Cotranscriptional exon skipping in the genotoxic stress response
Martin Dutertre et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)
Anti-tumor activity of splice-switching oligonucleotides
John A. Bauman et al.
NUCLEIC ACIDS RESEARCH (2010)
Disturbed Expression of Splicing Factors in Renal Cancer Affects Alternative Splicing of Apoptosis Regulators, Oncogenes, and Tumor Suppressors
Agnieszka Piekielko-Witkowska et al.
PLOS ONE (2010)
The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism
Cynthia V. Clower et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Pro-metastatic splicing of Ron proto-oncogene mRNA can be reversed: Therapeutic potential of bifunctional oligonucleotides and indole derivatives
Claudia Ghigna et al.
RNA BIOLOGY (2010)
Apoptosis of human melanoma cells induced by inhibition of B-RAFV600E involves preferential splicing of bimS
C. C. Jiang et al.
CELL DEATH & DISEASE (2010)
Significance of nuclear hTra2-beta1 expression in cervical cancer
Boris Gabriel et al.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA (2009)
The SR protein family of splicing factors: master regulators of gene expression
Jennifer C. Long et al.
BIOCHEMICAL JOURNAL (2009)
TGF-β regulates the expression of transcription factor KLF6 and its splice variants and promotes co-operative transactivation of common target genes through a Smad3-Sp1-KLF6 interaction
Luisa M. Botella et al.
BIOCHEMICAL JOURNAL (2009)
Structure-activity relationship of isoform selective inhibitors of Rac1/1b GTPase nucleotide binding
Eric Beausoleil et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
DNA Damage Regulates Alternative Splicing through Inhibition of RNA Polymerase II Elongation
Manuel J. Munoz et al.
CELL (2009)
RNA-binding motif protein 35A is a novel tumor suppressor for colorectal cancer
Olga V. Leontieva et al.
CELL CYCLE (2009)
Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo
Sumanta Goswami et al.
CLINICAL & EXPERIMENTAL METASTASIS (2009)
Modification of Alternative Splicing of Mcl-1 Pre-mRNA Using Antisense Morpholino Oligonucleotides Induces Apoptosis in Basal Cell Carcinoma Cells
Jeng-Jer Shieh et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2009)
RON receptor tyrosine kinase in human gliomas: expression, function, and identification of a novel soluble splice variant
Carmen Eckerich et al.
JOURNAL OF NEUROCHEMISTRY (2009)
Human oral cancers have altered expression of Bcl-2 family members and increased expression of the anti-apoptotic splice variant of Mcl-1
S. Mallick et al.
JOURNAL OF PATHOLOGY (2009)
Auto- and Cross-Regulation of the hnRNP L Proteins by Alternative Splicing
Oliver Rossbach et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
An oncogenic isoform of HER2 associated with locally disseminated breast cancer and trastuzumab resistance
Doyel Mitra et al.
MOLECULAR CANCER THERAPEUTICS (2009)
Cyclin D1b Variant Promotes Cell Invasiveness Independent of Binding to CDK4 in Human Bladder Cancer Cells
Chul Jang Kim et al.
MOLECULAR CARCINOGENESIS (2009)
ESRP1 and ESRP2 Are Epithelial Cell-Type-Specific Regulators of FGFR2 Splicing
Claude C. Warzecha et al.
MOLECULAR CELL (2009)
Chromatin Binding of SRp20 and ASF/SF2 and Dissociation from Mitotic Chromosomes Is Modulated by Histone H3 Serine 10 Phosphorylation
Rebecca J. Loomis et al.
MOLECULAR CELL (2009)
Cyclin D1b protein expression in breast cancer is independent of cyclin D1a and associated with poor disease outcome
E. K. A. Millar et al.
ONCOGENE (2009)
P19 H-Ras Induces G1/S Phase Delay Maintaining Cells in a Reversible Quiescence State
Maria Camats et al.
PLOS ONE (2009)
The epithelial splicing factors ESRP1 and ESRP2 positively and negatively regulate diverse types of alternative splicing events
Claude C. Warzecha et al.
RNA BIOLOGY (2009)
VEGF165b, an antiangiogenic VEGF-A isoform, binds and inhibits bevacizumab treatment in experimental colorectal carcinoma:: balance of pro- and antiangiogenic VEGF-A isoforms has implications for therapy
A. H. R. Varey et al.
BRITISH JOURNAL OF CANCER (2008)
The endogenous anti-angiogenic VEGF isoform, VEGF(165)b inhibits human tumour growth in mice
E. S. Rennel et al.
BRITISH JOURNAL OF CANCER (2008)
A functional role for KLF6-SV1 in lung adenocarcinoma prognosis and chemotherapy response
Analisa Difeo et al.
CANCER RESEARCH (2008)
Cyclin D1b is aberrantly regulated in response to therapeutic challenge and promotes resistance to estrogen antagonists
Ying Wang et al.
CANCER RESEARCH (2008)
A Mena Invasion Isoform Potentiates EGF-Induced Carcinoma Cell Invasion and Metastasis
Ulrike Philippar et al.
DEVELOPMENTAL CELL (2008)
Increased alternative splicing of the KLF6 tumour suppressor gene correlates with prognosis and tumour grade in patients with pancreatic cancer
Mark Hartel et al.
EUROPEAN JOURNAL OF CANCER (2008)
Recombinant human VEGF165b protein is an effective anti-cancer agent in mice
Emma S. Rennel et al.
EUROPEAN JOURNAL OF CANCER (2008)
Ras promotes growth by alternative splicing-mediated inactivation of the KLF6 tumor suppressor in hepatocellular carcinoma
Steven Yea et al.
GASTROENTEROLOGY (2008)
Expression of cyclin D1 splice variants is differentially associated with outcome in non-small cell lung cancer patients
Rong Li et al.
HUMAN PATHOLOGY (2008)
The Biflavonoid Isoginkgetin Is a General Inhibitor of Pre-mRNA Splicing
Kristine O'Brien et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Polypyrimidine tract-binding protein (PTB) differentially affects malignancy in a cell line-dependent manner
Chen Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5′ splice site selection
AnYu Zhou et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
HnRNP H and hnRNP F complex with Fox2 to silence fibroblast growth factor receptor 2 Exon IIIc
David M. Mauger et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Regulation of multiple core spliceosomal proteins by alternative splicing-coupled nonsense-mediated mRNA decay
Arneet L. Saltzman et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Increased Rac1b expression sustains colorectal tumor cell survival
Paulo Matos et al.
MOLECULAR CANCER RESEARCH (2008)
Involvement of fibroblast growth factor receptor 2 isoform switching in mammary oncogenesis
Jiyoung Y. Cha et al.
MOLECULAR CANCER RESEARCH (2008)
Anticancer drugs affect the alternative splicing of Bcl-x and other human apoptotic genes
Lulzim Shkreta et al.
MOLECULAR CANCER THERAPEUTICS (2008)
RBM5/Luca-15/H37 Regulates Fas Alternative Splice Site Pairing after Exon Definition
Sophie Bonnal et al.
MOLECULAR CELL (2008)
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
Heather R. Christofk et al.
NATURE (2008)
Up-regulation of the proapoptotic caspase 2 splicing isoform by a candidate tumor suppressor, RBM5
Kazuo Fushimi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Genes involved in pre-mRNA 3′-end formation and transcription termination revealed by a lin-15 operon Muv suppressor screen
Mingxue Cui et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The β-catenin/TCF4 pathway modifies alternative splicing through modulation of SRp20 expression
Vania Goncalves et al.
RNA (2008)
A cell-based screen for splicing regulators identifies hnRNP LL as a distinct signal-induced repressor of CD45 variable exon 4
Justin D. Topp et al.
RNA (2008)
Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL
Shalini Oberdoerffer et al.
SCIENCE (2008)
VEGF-A splicing: the key to anti-angiogenic therapeutics?
Steven J. Harper et al.
NATURE REVIEWS CANCER (2008)
Multiple variants of the RON receptor tyrosine kinase: Biochemical properties, tumorigenic activities, and potential drug targets
Yi Lu et al.
CANCER LETTERS (2007)
Functional inactivation of the KLF6 tumor suppressor gene by loss of heterozygosity and increased alternative splicing in glioblastoma
Olga Camacho-Vanegas et al.
INTERNATIONAL JOURNAL OF CANCER (2007)
Increased expression of SRp40 affecting CD44 splicing is associated with the clinical outcome of lymph node metastasis in human breast cancer
Chiun-Sheng Huang et al.
CLINICA CHIMICA ACTA (2007)
Expression of VEGFxxxb, the inhibitory isoforms of VEGF, in malignant melanoma
R. O. Pritchard-Jones et al.
BRITISH JOURNAL OF CANCER (2007)
Knockdown of polypyrimidine tract-binding protein suppresses ovarian tumor cell growth and invasiveness in vitro
X. He et al.
ONCOGENE (2007)
Loss-of-function screening by randomized intracellular antibodies: Identification of hnRNP-K as a potential target for metastasis
Atsushi Inoue et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Unproductive splicing of SR genes associated with highly conserved and ultraconserved DNA elements
Liana F. Lareau et al.
NATURE (2007)
Expression of RBM5-related factors in primary breast tissue
Nina D. Rintala-Maki et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2007)
Global analysis of alternative splicing during T-cell activation
Joanna Y. Ip et al.
RNA (2007)
Ultraconserved elements are associated with homeostatic control of splicing regulators by alternative splicing and nonsense-mediated decay
Julie Z. Ni et al.
GENES & DEVELOPMENT (2007)
Molecular cloning of hMena (ENAH) and its splice variant hMena+11a:: Epidermal growth factor increases their expression and stimulates hMena+11a phosphorylation in breast cancer cell lines
Francesca Di Modugno et al.
CANCER RESEARCH (2007)
The gene encoding the splicing factor SF2/ASF is a proto-oncogene
Rotem Karni et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2007)
The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x
Maria Paola Paronetto et al.
JOURNAL OF CELL BIOLOGY (2007)
Serine-arginine protein kinase 1 overexpression is associated with tumorigenic imbalance in mitogen-activated protein kinase pathways in breast, colonic, and pancreatic carcinomas
Gregory M. Hayes et al.
CANCER RESEARCH (2007)
A nucleo-cytoplasmic SR protein functions in viral IRES-mediated translation initiation
Kristin M. Bedard et al.
EMBO JOURNAL (2007)
The Drosophila heterogeneous nuclear ribonucleoprotein M protein, HRP59, regulates alternative splicing and controls the production of its own mRNA
Manuela E. Hase et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: Role of fibroblast growth factor receptor-2
Christine L. Chaffer et al.
CANCER RESEARCH (2006)
Heterogeneous nuclear ribonucleoprotein K is over expressed, aberrantly localised and is associated with poor prognosis in colorectal cancer
B. Carpenter et al.
BRITISH JOURNAL OF CANCER (2006)
Relevance of cyclin D1b expression and CCND1 polymorphism in the pathogenesis of multiple myeloma and mantle cell lymphoma
Sophie Krieger et al.
BMC CANCER (2006)
Alternative inclusion of fibroblast growth factor receptor 2 exon IIIc in Dunning prostate tumors reveals unexpected epithelial mesenchymal plasticity
Sebastian Oltean et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Up-regulation of MyD88s and SIGIRR, molecules inhibiting Toll-like receptor signaling, in monocytes from septic patients
Minou Adib-Conquy et al.
CRITICAL CARE MEDICINE (2006)
Rac1, but not Rac1B, stimulates RelB-mediated gene transcription in colorectal cancer cells
P Matos et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Splicing factor Tra2-β1 is specifically induced in breast cancer and regulates alternative splicing of the CD44 gene
Dirk O. Watermann et al.
CANCER RESEARCH (2006)
3p21.3 Tumor suppressor gene H37/Luca15/RBM5 inhibits growth of human lung cancer cells through cell cycle arrest and apoptosis
JJ Oh et al.
CANCER RESEARCH (2006)
Role of exon-16-deleted HER2 in breast carcinomas
F Castiglioni et al.
ENDOCRINE-RELATED CANCER (2006)
Cyclin D1b variant influences prostate cancer growth through aberrant androgen receptor regulation
CJ Burd et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Cell motility is controlled by SF2/ASF through alternative splicing of the Ron protooncogene
C Ghigna et al.
MOLECULAR CELL (2005)
hnRNP K: An HDM2 target and transcriptional coactivator of p53 in response to DNA damage
A Moumen et al.
CELL (2005)
Concerted regulation of nuclear and cytoplasmic activities of SR proteins by AKT
M Blaustein et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2005)
Differential expression of CD45 isoforms is controlled by the combined activity of basal and inducible splicing-regulatory elements in each of the variable exons
A Tong et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Delineation of the minimal commonly deleted segment and identification of candidate tumor-suppressor genes in del(9q) acute myeloid leukemia
DA Sweetser et al.
GENES CHROMOSOMES & CANCER (2005)
Interplay between SRPK and Clk/Sty kinases in phosphorylation of the splicing factor ASF/SF2 is regulated by a docking motif in ASF/SF2
JCK Ngo et al.
MOLECULAR CELL (2005)
Regulation of fas alternative splicing by antagonistic effects of TIA-1 and PTB on exon definition
JM Izquierdo et al.
MOLECULAR CELL (2005)
Targeted inhibition of the KLF6 splice variant, KLF6 SV1, suppresses prostate cancer cell growth and spread
G Narla et al.
CANCER RESEARCH (2005)
Selective inhibition of topoisomerase I and various steps of spliceosome assembly by diospyrin derivatives
J Tazi et al.
MOLECULAR PHARMACOLOGY (2005)
A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk
G Narla et al.
CANCER RESEARCH (2005)
Bcl-XL down-regulation suppresses the tumorigenic potential of NPM/ALK in vitro and in vivo
AML Coluccia et al.
BLOOD (2004)
Human tra2-beta1 autoregulates its protein concentration by influencing alternative splicing of its pre-mRNA
P Stoilov et al.
HUMAN MOLECULAR GENETICS (2004)
Alternative splicing of Rac1 generates Rac1b, a self-activating GTPase
D Fiegen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Alternative splicing of Bcl-2-related genes: functional consequences and potential therapeutic applications
C Akgul et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2004)
Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation
A Singh et al.
ONCOGENE (2004)
Alternative splicing of the multidrug resistance protein 1/ATP binding cassette transporter subfamily gene in ovarian cancer creates functional splice variants and is associated with increased expression of the splicing factors PTB and SRp20
XL He et al.
CLINICAL CANCER RESEARCH (2004)
Prostate cancer invasion is influenced more by expression of a CD44 isoform including variant 9 than by Muc18
AL Omara-Opyene et al.
LABORATORY INVESTIGATION (2004)
RNA-mediated gene silencing of the RON receptor tyrosine kinase alters oncogenic phenotypes of human colorectal carcinoma cells
XM Xu et al.
ONCOGENE (2004)
VEGF165b, an inhibitory vascular endothelial growth factor splice variant:: Mechanism of action, in vivo effect on angiogenesis and endogenous protein expression
J Woolard et al.
CANCER RESEARCH (2004)
Correction of aberrant FGFR1 alternative RNA splicing through targeting of intronic regulatory elements
IG Bruno et al.
HUMAN MOLECULAR GENETICS (2004)
Tumor-related alternatively spliced Rac1b is not regulated by Rho-GDP dissociation inhibitors and exhibits selective downstream signaling
P Matos et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Cyclin D1 splice variants - Differential effects on localization, RB phosphorylation, and cellular transformation
DA Solomon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization
GC Scheper et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Correction of disease-associated exon skipping by synthetic exon-specific activators
L Cartegni et al.
NATURE STRUCTURAL BIOLOGY (2003)
Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential
YQ Zhou et al.
ONCOGENE (2003)
Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans
BP Lewis et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Study of the 2719 mutant of the c-H-ras oncogene in a bi-intronic alternative splicing system
S Guil et al.
ONCOGENE (2002)
IIIc isoform of fibroblast growth factor receptor 1 is overexpressed in human pancreatic cancer and enhances tumorigenicity of hamster ductal cells
M Kornmann et al.
GASTROENTEROLOGY (2002)
Regulation of fibronectin alternative splicing by a basement membrane-like extracellular matrix
A Srebrow et al.
FEBS LETTERS (2002)
Expression of early lung cancer detection marker: hnRNP-A2/B1 and its relation to microsatellite alteration in non-small cell lung cancer
J Zhou et al.
LUNG CANCER (2001)
Insulin regulates alternative splicing of protein kinase C βII through a phosphatidylinositol 3-kinase-dependent pathway involving the nuclear serine/arginine-rich splicing factor, SRp40, in skeletal muscle cells
NA Patel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Modification of alternative splicing of Bcl-x Pre-mRNA in prostate and breast cancer cells - Analysis of apoptosis and cell death
DR Mercatante et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
SC35 autoregulates its expression by promoting splicing events that destabilize its mRNAs
A Sureau et al.
EMBO JOURNAL (2001)
Differential expression of the early lung cancer detection marker, heterogeneous nuclear ribonucleoprotein-A2/B1 (hnRNP-A2/B1) in normal breast and neoplastic breast cancer
J Zhou et al.
BREAST CANCER RESEARCH AND TREATMENT (2001)
Growth factors regulate heterogeneous nuclear ribonucleoprotein K expression and function
M Mandal et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
SC35 plays a role in T cell development and alternative splicing of CD45
HY Wang et al.
MOLECULAR CELL (2001)
MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain
J Bae et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Deletion of individual exons and induction of soluble murine interleukin-5 receptor-α chain expression through antisense oligonucleotide-mediated redirection of pre-mRNA splicing
JG Karras et al.
MOLECULAR PHARMACOLOGY (2000)
Exon skipping in Mcl-1 results in a Bcl-2 homology domain 3 only gene product that promotes cell death
CD Bingle et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b
A Schnelzer et al.
ONCOGENE (2000)
A human importin-β family protein, transportin-SR2, interacts with the phosphorylated RS domain of SR proteins
MC Lai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Soluble Fas in serum from patients with renal cell carcinoma
N Nonomura et al.
UROLOGY (2000)
Share Paper
