Journal
POLYMERS
Volume 10, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/polym10050521
Keywords
skin and soft tissue infections; polyhexamethylene biguanide; nadifloxacin; nanoparticles; intracellular MRSA
Categories
Funding
- SLAB Scheme, Ministry of Education, Malaysia [851209035040]
- Maplethorpe Postdoctoral Fellowships of the University of London
- BBSRC LIDo studentship [156780]
- BBSRC [BB/R022569/1] Funding Source: UKRI
Ask authors/readers for more resources
The treatment of skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus (MRSA) remains a challenge, partly due to localization of the bacteria inside the host's cells, where antimicrobial penetration and efficacy is limited. We formulated the cationic polymer polyhexamethylene biguanide (PHMB) with the topical antibiotic nadifloxacin and tested the activities against intracellular MRSA in infected keratinocytes. The PHMB/nadifloxacin nanoparticles displayed a size of 291.3 +/- 89.6 nm, polydispersity index of 0.35 +/- 0.04, zeta potential of +20.2 +/- 4.8 mV, and drug encapsulation efficiency of 58.25 +/- 3.4%. The nanoparticles killed intracellular MRSA, and relative to free polymer or drugs used separately or together, the nanoparticles displayed reduced toxicity and improved host cell recovery. Together, these findings show that PHMB/nadifloxacin nanoparticles are effective against intracellular bacteria and could be further developed for the treatment of skin and soft tissue infections.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available