Journal
NEOPLASMA
Volume 59, Issue 3, Pages 248-256Publisher
VEDA, SLOVAK ACAD SCIENCES
DOI: 10.4149/neo_2012_032
Keywords
perifosine; PI3K/Akt; breast cancer; multidrug resistant gene 1; P-glycoprotein
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Funding
- Scientific Research Foundation for the Excellent Middle-Aged and Youth Scientists of Shandong Province of China [BS2009YY033]
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P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) is the major clinical impediment to chemotherapy of breast cancers. Down-regulation of PI3K/Akt pathway has been described as related to reversal of MDR in cancer cells. Here, we investigated the reversal effect on MDR phenotype of perifosine, a new Akt inhibitor, in breast cancer cell lines. In this study, MCF-7/ADM cells and MCF-7 cells were treated with different concentrations of perifosine. Our results suggested that perifosine reversed MDR partially by downregulation of P-gp expression and inhibition of PI3K/Akt/NF-kappa B pathway in the MCF-7/ADM cell line. The novel Akt inhibitor perifosine may be a promising new drug due to its ability to reverse MDR in human breast cancer cells.
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