Journal
JOURNAL OF MATERIALS CHEMISTRY
Volume 22, Issue 16, Pages 7692-7696Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2jm30848g
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Funding
- National Natural Science Foundation of China (NNSFC) [51010004, 51073100]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1163]
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- le Fonds quebecois de la recherche sur la nature et les technologies of Quebec (FQRNT)
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In this paper, we report a new modality enabling the simultaneous control of shape memory polymers (SMPs) and release of loaded drugs. The approach uses high intensity focused ultrasound (HIFU) and explores localized heating of SMPs upon HIFU exposure. We show that the HIFU-triggered shape recovery process can be spatially and temporarily controlled, allowing the shape memory effect to manifest in selected regions on demand, endowing SMPs with the capability of adopting multiple intermediate shapes and synchronizing the release of loaded drugs in a switchable manner. To our knowledge, this is the first time that HIFU is utilized as a trigger to reveal these appealing features of SMPs.
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