Journal
MRS COMMUNICATIONS
Volume 8, Issue 3, Pages 955-960Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1557/mrc.2018.102
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Funding
- National Research Foundation of Korea - Ministry of Education, Science and Technology [2013M2B2B1075774, 2015 M2A2A7A1045270]
- National Research Foundation of Korea [2013M2B2B1075774] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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In in vitro separate compartment model of neuronal cells and extracellular iron oxide nanoparticles (IONs)-amyloid complexes. a traversing proton-induced Coulomb nanoradiator effect (CNR) was found to break up the ION-amyloid fibrils and to induce redox changes in the IONs. We found that the CNR effect caused the conversion of redox-active iron (II) into redox-inactive iron (III) as well as the disruption of the ION-amyloid fibrils without significantly damaging normal neuronal cells. Our observations suggest a non-invasive redox inactivation and beta-amyloidolyis-based therapy of neurotoxic A beta plaque involving a traversing proton Coulomb nanochelator that would not substantially impact normal neuronal cells.
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