Journal
AMERICAN JOURNAL OF OPHTHALMOLOGY
Volume 159, Issue 4, Pages 667-676Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ajo.2015.01.001
Keywords
-
Categories
Funding
- National Research Foundation of South Korea (NRF) - Ministry of Education, Science and Technology, Daejeon, South Korea [2012R1A2A2A02012821]
- National Research Foundation of Korea [2012R1A2A2A02012821] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Ask authors/readers for more resources
PURPOSE: To investigate the retinal and choroidal changes using spectral-domain optical coherence tomography (SD OCT) and to identify factors associated with visual outcome in eyes with central retinal artery occlusion (CRAO). DESIGN: Retrospective, observational case series. METHODS: SETTING: Institutional. PATIENTS: A total of 134 eyes diagnosed with acute (symptom onset 5 7 days) nonarteritic CRAO examined with SD OCT at baseline and follow-up visits. OBSERVATIONS: Based on funduscopic and angiographic findings, CRAO was categorized into 3 stages: incomplete, subtotal, and total. Abnormal morphologic features were evaluated from SD OCT images. Central macular thickness (CMT), inner and outer retinal thicknesses, and subfoveal choroidal thickness (SFCT) were measured. The clinical and SD OCT features were correlated with the final best-corrected visual acuities (BCVA). MAIN OUTCOME MEASURES: Retinal and choroidal thickness and BCVA. RESULTS: Features of SD OCT at the initial presentation included inner and outer retinal thickening. At baseline, the frequency of inner and outer retinal thickening and macular edema (CMT > 300 mu m) differed significantly among CRAO stages (all P < .05). SFCT in eyes with total CRAO was significantly thinner compared with that of the contralateral eyes (P = .009). A higher CRAO stage was associated significantly with macular edema at baseline (P < .001) and retinal thinning at the final visit (P = .010). Baseline CMT was correlated significantly with final BCVA (P < .001). Multivariate logistic regression analyses revealed that severe vision loss (BCVA < 20/200) was associated significantly with CRAO stage (P < .001) and baseline CMT (P = .005). CONCLUSIONS: CRAO resulted in inner and outer retinal thickening in the acute stages and subsequent atrophic changes in the inner and outer retina. SD OCT may be a useful noninvasive imaging tool for diagnosis, staging, and prognosis of CRAO. (C) 2015 by Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available