4.4 Review

Gene Therapy for Parkinson's Disease, An Update

Related references

Note: Only part of the references are listed.
Review Biochemical Research Methods

Leucine-rich repeat kinase 2 and Parkinson's disease

Un-Beom Kang et al.

PROTEOMICS (2017)

Review Genetics & Heredity

Exploring the potential of genome editing CRISPR-Cas9 technology

Vijai Singh et al.

Article Nanoscience & Nanotechnology

Regulation of human GDNF gene expression in nigral dopaminergic neurons using a new doxycycline-regulated NTS-polyplex nanoparticle system

Armando J. Espadas-Alvarez et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2017)

Article Nanoscience & Nanotechnology

Intracerebral injections of DNA nanoparticles encoding for a therapeutic gene provide partial neuroprotection in an animal model of neurodegeneration

David Yurek et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2017)

Editorial Material Genetics & Heredity

Early Insights from Commercialization of Gene Therapies in Europe

Nicolas Touchot et al.

GENES (2017)

Article Biotechnology & Applied Microbiology

Persistent Expression of Dopamine-Synthesizing Enzymes 15 Years After Gene Transfer in a Primate Model of Parkinson's Disease

Yoshihide Sehara et al.

HUMAN GENE THERAPY CLINICAL DEVELOPMENT (2017)

Review Pharmacology & Pharmacy

Chemogenetic Modulation of G Protein-Coupled Receptor Signalling in Visual Attention Research

Soren H. Jorgensen et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2017)

Article Medicine, Research & Experimental

Long-term follow-up of a randomized AAV2-GAD gene therapy trial for Parkinson's disease

Martin Niethammer et al.

JCI INSIGHT (2017)

Review Clinical Neurology

The genetic background of Parkinson's disease: current progress and future prospects

K. Kalinderi et al.

ACTA NEUROLOGICA SCANDINAVICA (2016)

Review Clinical Neurology

Optogenetic Approaches for Controlling Seizure Activity

Jack K. Tung et al.

BRAIN STIMULATION (2016)

Review Neurosciences

Nurr1-Based Therapies for Parkinson's Disease

Jie Dong et al.

CNS NEUROSCIENCE & THERAPEUTICS (2016)

Review Clinical Neurology

Surgical Treatment of Parkinson's Disease

Leo Verhagen Metman et al.

CURRENT TREATMENT OPTIONS IN NEUROLOGY (2016)

Correction Medicine, Research & Experimental

Combined Nurr1 and Foxa2 roles in the therapy of Parkinson's disease (vol 7, pg 510, 2015)

Sang-Min Oh et al.

EMBO MOLECULAR MEDICINE (2016)

Article Biochemistry & Molecular Biology

Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces -Synuclein Aggregation

Jordan Follett et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Neurosciences

Teaching neurons to respond to placebos

Fabrizio Benedetti et al.

JOURNAL OF PHYSIOLOGY-LONDON (2016)

News Item Multidisciplinary Sciences

First trial of CRISPR in people

David Cyranoski

NATURE (2016)

Review Neurosciences

Neuropeptide Y (NPY) as a therapeutic target for neurodegenerative diseases

Joana Duarte-Neves et al.

NEUROBIOLOGY OF DISEASE (2016)

Article Neurosciences

Developing therapeutically more efficient Neurturin variants for treatment of Parkinson's disease

Pia Runeberg-Roos et al.

NEUROBIOLOGY OF DISEASE (2016)

Review Neurosciences

DREADDs for Neuroscientists

Bryan L. Roth

NEURON (2016)

Review Neurosciences

PROBING PAIN PATHWAYS WITH LIGHT

Feng Wang et al.

NEUROSCIENCE (2016)

Article Multidisciplinary Sciences

Human striatal recordings reveal abnormal discharge of projection neurons in Parkinson's disease

Arun Singh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Review Neurosciences

CRISPR/Cas9: Implications for Modeling and Therapy of Neurodegenerative Diseases

Weili Yang et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2016)

Review Ophthalmology

Optogenetics

Jens Duebel et al.

CURRENT OPINION IN OPHTHALMOLOGY (2015)

Article Medicine, General & Internal

Lewy body dementias

Zuzana Walker et al.

LANCET (2015)

Article Biotechnology & Applied Microbiology

Enhanced Efficacy of the CDNF/MANF Family by Combined Intranigral Overexpression in the 6-OHDA Rat Model of Parkinson's Disease

Oscar Cordero-Llana et al.

MOLECULAR THERAPY (2015)

News Item Multidisciplinary Sciences

CRISPR, THE DISRUPTOR

Heidi Ledford

NATURE (2015)

Article Anatomy & Morphology

An animal model mimicking pedunculopontine nucleus cholinergic degeneration in Parkinson's disease

Ilse S. Pienaar et al.

BRAIN STRUCTURE & FUNCTION (2015)

Article Clinical Neurology

DNAJC13 Genetic Variants in Parkinsonism

Emil K. Gustavsson et al.

MOVEMENT DISORDERS (2015)

Article Neurosciences

Noninvasive optical inhibition with a red-shifted microbial rhodopsin

Amy S. Chuong et al.

NATURE NEUROSCIENCE (2014)

Article Neurosciences

Titer and Product Affect the Distribution of Gene Expression after Intraputaminal Convection-Enhanced Delivery

Marina E. Emborg et al.

STEREOTACTIC AND FUNCTIONAL NEUROSURGERY (2014)

Review Cardiac & Cardiovascular Systems

Cardiac optogenetics

Emilia Entcheva

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2013)

Article Neurosciences

Control of Basal Ganglia Output by Direct and Indirect Pathway Projection Neurons

Benjamin S. Freeze et al.

JOURNAL OF NEUROSCIENCE (2013)

Article Geriatrics & Gerontology

NRSF/REST neuronal deficient mice are more vulnerable to the neurotoxin MPTP

Mei Yu et al.

NEUROBIOLOGY OF AGING (2013)

Article Multidisciplinary Sciences

TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity

Mickael Decressac et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Biochemistry & Molecular Biology

An ERcentric view of Parkinson's disease

Gabriela Mercado et al.

TRENDS IN MOLECULAR MEDICINE (2013)

Review Pharmacology & Pharmacy

Novel designer receptors to probe GPCR signaling and physiology

Juergen Wess et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2013)

Article Biotechnology & Applied Microbiology

Long-Term Evaluation of a Phase 1 Study of AADC Gene Therapy for Parkinson's Disease

Gabriele Mittermeyer et al.

HUMAN GENE THERAPY (2012)

Review Nanoscience & Nanotechnology

NTS-Polyplex: a potential nanocarrier for neurotrophic therapy of Parkinson's disease

Daniel Martinez-Fong et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2012)

Article Geriatrics & Gerontology

Neuroprotection by neuropeptide Y in cell and animal models of Parkinson's disease

Mickael Decressac et al.

NEUROBIOLOGY OF AGING (2012)

Review Neurosciences

Viral vectors for gene delivery to the central nervous system

Thomas B. Lentz et al.

NEUROBIOLOGY OF DISEASE (2012)

Article Neurosciences

An optogenetic toolbox designed for primates

Ilka Diester et al.

NATURE NEUROSCIENCE (2011)

Article Biochemistry & Molecular Biology

The TrkB-Positive Dopaminergic Neurons are Less Sensitive to MPTP Insult in the Substantia Nigra of Adult C57/BL Mice

Yin-Xiu Ding et al.

NEUROCHEMICAL RESEARCH (2011)

Article Multidisciplinary Sciences

TFEB Links Autophagy to Lysosomal Biogenesis

Carmine Settembre et al.

SCIENCE (2011)

Review Biochemistry & Molecular Biology

The Yin and Yang of VEGF and PEDF: Multifaceted Neurotrophic Factors and Their Potential in the Treatment of Parkinson's Disease

Torsten Falk et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2010)

Article Neurosciences

Pathogenic Lysosomal Depletion in Parkinson's Disease

Benjamin Dehay et al.

JOURNAL OF NEUROSCIENCE (2010)

Article Biotechnology & Applied Microbiology

Eight Years of Clinical Improvement in MPTP-Lesioned Primates After Gene Therapy With AAV2-hAADC

Piotr Hadaczek et al.

MOLECULAR THERAPY (2010)

Article Biotechnology & Applied Microbiology

A Phase I Study of Aromatic L-Amino Acid Decarboxylase Gene Therapy for Parkinson's Disease

Shin-ichi Muramatsu et al.

MOLECULAR THERAPY (2010)

Article Multidisciplinary Sciences

Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry

Alexxai V. Kravitz et al.

NATURE (2010)

Review Neurosciences

α-Synuclein and dopamine at the crossroads of Parkinson's disease

Lara Lourenco Venda et al.

TRENDS IN NEUROSCIENCES (2010)

Article Biotechnology & Applied Microbiology

Functional Effects of AAV2-GDNF on the Dopaminergic Nigrostriatal Pathway in Parkinsonian Rhesus Monkeys

Jamie L. Eberling et al.

HUMAN GENE THERAPY (2009)

Review Clinical Neurology

Brain-derived neurotrophic factor in neurodegenerative diseases

Chiara Zuccato et al.

NATURE REVIEWS NEUROLOGY (2009)

Article Clinical Neurology

Safety and tolerability of putaminal AADC gene therapy for Parkinson disease

C. W. Christine et al.

NEUROLOGY (2009)

Article Multidisciplinary Sciences

Optical Deconstruction of Parkinsonian Neural Circuitry

Viviana Gradinaru et al.

SCIENCE (2009)

Article Cell Biology

Dopamine Gene Therapy for Parkinson's Disease in a Nonhuman Primate Without Associated Dyskinesia

Bechir Jarraya et al.

SCIENCE TRANSLATIONAL MEDICINE (2009)

Article Oncology

Armet, a UPR-upregulated protelin, inhibits cell proliferation and ER stress-induced cell death

Andria Apostolou et al.

EXPERIMENTAL CELL RESEARCH (2008)

Article Clinical Neurology

Decreased NURR1 gene expression in patients with Parkinson's disease

Weidong Le et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2008)

Article Biotechnology & Applied Microbiology

Transgene expression, bioactivity, and safety of CERE-120 (AAV2-neurturin) following delivery to the monkey striatum

Christopher D. Herzog et al.

MOLECULAR THERAPY (2008)

Article Biochemical Research Methods

Engineering GPCR signaling pathways with RASSLs

Bruce R. Conklin et al.

NATURE METHODS (2008)

Article Clinical Neurology

Results from a phase I safety trial of hAADC gene therapy for Parkinson disease

J. L. Eberling et al.

NEUROLOGY (2008)

Article Multidisciplinary Sciences

Modulation of metabolic brain networks after subthalamic gene therapy for Parkinson's disease

Andrew Feigin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Multidisciplinary Sciences

Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo

Pivi Lindholm et al.

NATURE (2007)

Article Endocrinology & Metabolism

Subthalamic glutamic acid decarboxylase gene therapy: changes in motor function and cortical metabolism

Marina E. Emborg et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2007)

Article Biotechnology & Applied Microbiology

Long-term clinical improvement in MPTP-lesioned primates after gene therapy with AAV-hAADC

Krystof S. Bankiewicz et al.

MOLECULAR THERAPY (2006)

Article Biotechnology & Applied Microbiology

A dose-ranging study of AAV-hAADC therapy in parkinsonian monkeys

John R. Forsayeth et al.

MOLECULAR THERAPY (2006)

Article Biotechnology & Applied Microbiology

Dimerizer regulation of AADC expression and behavioral response in AAV-transduced 6-OHDA lesioned rats

LM Sanftner et al.

MOLECULAR THERAPY (2006)

Article Biotechnology & Applied Microbiology

Viral-mediated temporally controlled dopamine production in a rat model of Parkinson disease

XG Li et al.

MOLECULAR THERAPY (2006)

Article Biochemistry & Molecular Biology

The DnaJ-domain protein RME-8 functions in endosomal trafficking

M Girard et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Review Neurosciences

The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease

J Jankovic et al.

PROGRESS IN NEUROBIOLOGY (2005)

Article Neurosciences

Intraputamenal infusion of GDNF in aged rhesus monkeys: Distribution and dopaminergic effects

Y Ai et al.

JOURNAL OF COMPARATIVE NEUROLOGY (2003)

Review Biochemistry & Molecular Biology

The biology of VEGF and its receptors

N Ferrara et al.

NATURE MEDICINE (2003)

Article Biochemistry & Molecular Biology

Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease

SS Gill et al.

NATURE MEDICINE (2003)

Article Biochemistry & Molecular Biology

MANF - A new mesencephalic, astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons

PS Petrova et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2003)

Review Medicine, Research & Experimental

Recent developments in our understanding of the physiological role of PP-fold peptide receptor subtypes

MM Berglund et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2003)

Article Neurosciences

Increased neuropeptide Y mRNA expression in striatum in Parkinson's disease

C Cannizzaro et al.

MOLECULAR BRAIN RESEARCH (2003)

Article Multidisciplinary Sciences

Subthalamic GAD gene therapy in a Parkinson's disease rat model

J Luo et al.

SCIENCE (2002)

Review Neurosciences

The GDNF family: Signalling, biological functions and therapeutic value

MS Airaksinen et al.

NATURE REVIEWS NEUROSCIENCE (2002)

Article Neurosciences

Effects of transient focal inactivation of the basal ganglia in parkinsonian primates

MS Baron et al.

JOURNAL OF NEUROSCIENCE (2002)

Review Cardiac & Cardiovascular Systems

The neuropilins: Multifunctional semaphorin and VEGF receptors that modulate axon guidance and angiogenesis

G Neufeld et al.

TRENDS IN CARDIOVASCULAR MEDICINE (2002)

Review Neurosciences

Trk receptors: mediators of neurotrophin action

A Patapoutian et al.

CURRENT OPINION IN NEUROBIOLOGY (2001)

Article Medicine, General & Internal

Association between early-onset Parkinson's disease and mutations in the parkin gene

CB Lücking et al.

NEW ENGLAND JOURNAL OF MEDICINE (2000)