Journal
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
Volume 64, Issue 9, Pages 2443-2452Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TIM.2015.2412000
Keywords
Blood pressure (BP); electrocardiogram (ECG); estimation; mathematical modeling; mean arterial pressure (MAP); oscillometry; pulse transit time (PTT)
Funding
- Ontario Ministry of Training, Colleges and Universities
- Ontario Ministry of Economic Development and Innovation
- Natural Sciences and Engineering Research Council of Canada
- Ontario Centres of Excellence
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An accurate noninvasive estimation of mean arterial pressure (MAP) is of great importance in the evaluation of circulatory function and prognosis of some cardiovascular diseases. This paper proposes a novel oscillometric MAP estimation method based on the dependence of pulse transit time (PTT) on cuff pressure (CP). The PTT computed as the time interval between the electrocardiogram (ECG) R-peaks and the maximum slope points on the oscillometric pulses is mathematically modeled by considering the cuff-arm-artery system and the blood flow dynamics. It is then analytically shown that MAP can be approximated as the CP at which the PTT is maximum. Based on our theoretical findings, a new method of MAP estimation from simultaneous ECG and oscillometric blood pressure measurements is proposed. Our proposed method is validated with a pilot study in which 150 recordings from 10 subjects are analyzed. The reference MAP is computed from the systolic and diastolic pressures measured by the Food and Drug Administrationapproved Omron HEM-7901T monitor using three different formulas given in the literature. The performance of our proposed method is compared with the maximum amplitude and zero-crossing methods in terms of mean error (ME), mean absolute error, and standard deviation of error (SDE). It is found that our proposed method achieves improvements of more than 20% in SDE compared with the maximum amplitude method and more than 50% in ME compared with the zero-crossing method.
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