Journal
NATURE REVIEWS IMMUNOLOGY
Volume 12, Issue 5, Pages 367-382Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri3210
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Funding
- US National Institutes of Health [R01AI068041-06]
- Burroughs Wellcome Fund Investigator in the Pathogenesis of Infectious Disease Award [1007845]
- Crohn's and Colitis Foundation [R09928]
- W.W. Winchester Award
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Interferons (IFNs) induce the expression of hundreds of genes as part of an elaborate antimicrobial programme designed to combat infection in all nucleated cells-a process termed cell-autonomous immunity. As described in this Review, recent genomic and subgenomic analyses have begun to assign functional properties to novel IFN-inducible effector proteins that restrict bacteria, protozoa and viruses in different subcellular compartments and at different stages of the pathogen life cycle. Several newly described host defence factors also participate in canonical oxidative and autophagic pathways by spatially coordinating their activities to enhance microbial killing. Together, these IFN-induced effector networks help to confer vertebrate host resistance to a vast and complex microbial world.
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