Journal
ORAL SCIENCE INTERNATIONAL
Volume 9, Issue 1, Pages 1-8Publisher
WILEY
DOI: 10.1016/S1348-8643(12)00009-2
Keywords
Osteocyte; OLCS; Sclerostin; FGF23; Bone remodeling
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Funding
- Japanese Society for the Promotion of Science
- Grants-in-Aid for Scientific Research [22592028, 22791760] Funding Source: KAKEN
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Osteocytes are organized in functional syncytia collectively referred to as the osteocytic lacunar-canalicular system (OLCS). The osteocytes are interconnected through gap junctions between their cytoplasmic processes, which pass through narrow passageways referred to as osteocytic canaliculi. There are two possible ways molecules can be transported throughout the OLCS: via the cytoplasmic processes and their gap junctions, and via the pericellular space in the osteocytic canaliculi. Transport of minerals and small molecules through a spatially well-organized OLCS is vital for bone mineral homeostasis, mechanosensing, and bone remodeling control. Recently, osteocyte-derived molecules - sclerostin, dentin matrix protein-1, fibroblast growth factor 23 (FGF23) - have been put in evidence as they may be related to osteocytic functions such as mechanosensing, regulation of bone remodeling, and so forth. FGF23 regulates serum phosphate concentration by affecting renal function, while sclerostin can inhibit osteoblastic activities. In our observations, FGF23 and sclerostin synthesis seemed to be associated with the spatial regularity of the OLCS. This review will introduce our recent morphological studies on the regularity of OLCS and the synthesis of osteocyte-derived FGF23 and sclerostin. (C) 2012 Japanese Stomatological Society. Published by Elsevier Ltd. All rights reserved.
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