Journal
GENOME MEDICINE
Volume 10, Issue -, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/s13073-018-0518-5
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Funding
- National Institutes of Health (NIH) [U19MH106434]
- NIH [R01MH105128, R35NS097370, U19AI131130, R37 NS047344, P01NS097206, R01AG057497]
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Breakthroughs on many fronts have provided strong evidence to support synaptic dysfunction as a causal factor for neuropsychiatric diseases. Genetic studies have identified variants implicated in novel biological and synaptic pathways, and animal and patient-derived induced pluripotent stem cell-based models have allowed mechanistic investigations of synaptic dysfunction in pathological processes.
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