Journal
CELL REPORTS
Volume 22, Issue 9, Pages 2421-2430Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2018.02.020
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Funding
- European Union's Seventh Framework Programme for Research, Technological Development and Demonstration [609396]
- Spanish MINECO [BFU2008-0196, BFU2010-17704]
- Generalitat de Catalunya [2009SGR809]
- bridge grants from the Dean for Research
- Departament de Ciencies Mediques Basiques of the University of Lleida
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Microorganisms evolved adaptive responses to survive stressful challenges in ever-changing environments. Understanding the relationships between the physiological/metabolic adjustments allowing cellular stress adaptation and gene expression changes being used by organisms to achieve such adjustments may significantly impact our ability to understand and/or guide evolution. Here, we studied those relationships during adaptation to various stress challenges in Saccharomyces cerevisiae, focusing on heat stress responses. We combined dozens of independent experiments measuring whole-genome gene expression changes during stress responses with a simplified kinetic model of central metabolism. We identified alternative quantitative ranges for a set of physiological variables in the model (production of ATP, trehalose, NADH, etc.) that are specific for adaptation to either heat stress or desiccation/rehydration. Our approach is scalable to other adaptive responses and could assist in developing biotechnological applications to manipulate cells for medical, biotechnological, or synthetic biology purposes.
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