Journal
CELL REPORTS
Volume 22, Issue 3, Pages 706-721Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2017.11.102
Keywords
-
Categories
Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [16390062, 19390059, 21390067, 24390058, 17659069, 15K15352, 22126005, 18790629, 20790656, 22790875, 24591374, 15K09405]
- Japan Society for the Promotion of Science
- NIH [R01 DK043051]
- JPB Foundation
- Grants-in-Aid for Scientific Research [16390062, 15K09405, 17659069, 19390059, 21390067, 22790875, 17K08557, 24591374, 16K19549, 18790629, 15K15352, 24390058, 15K16217, 20790656, 22126005] Funding Source: KAKEN
Ask authors/readers for more resources
Food selection is essential for metabolic homeostasis and is influenced by nutritional state, food palatability, and social factors such as stress. However, the mechanism responsible for selection between a high-carbohydrate diet (HCD) and a high-fat diet (HFD) remains unknown. Here, we show that activation of a subset of corticotropin-releasing hormone (CRH)-positive neurons in the rostral region of the paraventricular hypothalamus (PVH) induces selection of an HCD over an HFD in mice during refeeding after fasting, resulting in a rapid recovery from the change in ketone metabolism. These neurons manifest activation of AMP-activated protein kinase (AMPK) during food deprivation, and this activation is necessary and sufficient for selection of an HCD over an HFD. Furthermore, this effect is mediated by carnitine palmitoyltransferase 1c (CPT1c). Thus, our results identify the specific neurons and intracellular signaling pathway responsible for regulation of the complex behavior of selection between an HCD and an HFD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available