Journal
CELL REPORTS
Volume 23, Issue 8, Pages 2379-2391Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2018.04.073
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Funding
- Canadian Institutes of Health Research (CIHR) [MOP119421, PJT-155959]
- Canadian Natural Science and Engineering Research Council (NSERC) [RGPIN341498, RGPIN-2017-06295]
- Hospital for Sick Children
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Social interactions are essential to our mental health, and a deficit in social interactions is a hallmark characteristic of numerous brain disorders. Various subregions within the medial temporal lobe have been implicated in social memory, but the underlying mechanisms that tune these neural circuits remain unclear. Here, we demonstrate that optical activation of excitatory entorhinal cortical perforant projections to the dentate gyrus (EC-DG) is necessary and sufficient for social memory retrieval. We further show that inducible disruption of p21-activated kinase (PAK) signaling, a key pathway important for cyto-skeletal reorganization, in the EC-DG circuit leads to impairments in synaptic function and social recognition memory, and, importantly, optogenetic activation of the EC-DG terminals reverses the social memory deficits in the transgenic mice. These results provide compelling evidence that activation of the EC-DG pathway underlies social recognition memory recall and that PAK signaling may play a critical role in modulating this process.
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