Journal
CELL REPORTS
Volume 22, Issue 11, Pages 2873-2885Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2018.02.056
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Funding
- JSPS [25871135]
- Japan Agency for Medical Research and Development (AMED)
- Ministry of Education, Culture, Sports, Science, and Technology (MEXT)
- Funding Program for World-Leading Innovative R&D on Science and Technology (FIRST Program)
- [12J00301]
- Grants-in-Aid for Scientific Research [25871135, 15H04290] Funding Source: KAKEN
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Multisensory integration (MSI) is a fundamental emergent property of the mammalian brain. During MSI, perceptual information encoded in patterned activity is processed in multimodal association cortex. The systems-level neuronal dynamics that coordinate MSI, however, are unknown. Here, we demonstrate intrinsic hub-like network activity in the association cortex that regulates MSI. We engineered calcium reporter mouse lines based on the fluorescence resonance energy transfer sensor yellow cameleon (YC2.60) expressed in excitatory or inhibitory neurons. In medial and parietal association cortex, we observed spontaneous slow waves that self-organized into hubs defined by long-range excitatory and local inhibitory circuits. Unlike directional source/sink-like flows in sensory areas, medial/parietal excitatory and inhibitory hubs had net-zero balanced inputs. Remarkably, multisensory stimulation triggered rapid phase-locking mainly of excitatory hub activity persisting for seconds after the stimulus offset. Therefore, association cortex tends to form balanced excitatory networks that configure slow-wave phase-locking for MSI.
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