Journal
CELL REPORTS
Volume 23, Issue 3, Pages 682-691Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2018.03.082
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Funding
- NIH [R37 AI038518, R01 AI103981, R01 AI138709, T32 AI07140, F30 AI122866]
- NSF Graduate Research Fellowship [DGE-1256082]
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Eliciting broad and potent HIV-specific neutralizing antibody responses represents the holy grail of HIV vaccine efforts. Data from singly infected individuals with broad and potent plasma neutralizing activity targeting one epitope have guided our understanding of how these responses develop. However, far less is known about responses developed by superinfected individuals who acquire two distinct HIV strains. Here, we isolated HIV-specific mAbs from a superinfected individual with a broad plasma response. In this superinfection case, neutralizing activity resulted from multiple distinct B cell lineages that arose in response to either the initial or the superinfecting virus, including an antibody that targets the N332 supersite. This nAb, QA013.2, was specific to the superinfecting virus and was associated with eventual reemergence of the initial infecting virus. The complex dynamic between viruses in superinfection may drive development of a unique collection of polyclonal nAbs that present a higher barrier to escape than monoclonal responses.
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