Journal
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
Volume 17, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12941-018-0272-y
Keywords
Providencia rettgeri; Outbreak; Urinary tract infection; NDM-1; PER-1
Categories
Funding
- Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea [HI12C0756]
- Korea Health Promotion Institute [HI12C0756090016] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Background: Nosocomial outbreak due to carbapenem-resistant Enterobacteriaceae has become serious challenge to patient treatment and infection control. We describe an outbreak due to a multidrug-resistant Providencia rettgeri from January 2016 to January 2017 at a University Hospital in Seoul, Korea. Methods: A total of eight non-duplicate P. rettgeri isolates were discovered from urine samples from eight patients having a urinary catheter and admitted in a surgical intensive care unit. The beta-lactamase genes were identified using polymerase chain reaction and direct sequencing, and strain typing was done with pulsed-field gel electrophoresis (PFGE). Results: All isolates showed high-level resistance to extended-spectrum cephalosporins, aztreonam, meropenem, ertapenem, ciprofloxacin, and amikacin. They harbored the bla(NDM-1) carbapenemase and the bla(PER-1) type extendedspectrum beta-lactamases genes. PFGE revealed that all isolates from eight patients were closely related strains. Conclusions: The 13-month outbreak ended following reinforcement of infection control measures, including contact isolation precautions and environmental disinfection. This is the first report of an outbreak of a P. rettgeri clinical isolates co-producing NDM-1 and PER-1 beta-lactamase.
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