4.7 Article

Point-of-Care Identification of Bacteria Using Protein-Encapsulated Gold Nanoclusters

Journal

ADVANCED HEALTHCARE MATERIALS
Volume 7, Issue 13, Pages -

Publisher

WILEY
DOI: 10.1002/adhm.201701370

Keywords

bacteria; fluorescent probes; gold nanoclusters; sensor array

Funding

  1. 973 Project [2012CB720602]
  2. NSFC [21210002, 21431007, 21533008, 21673223]
  3. Key Program of Frontier of Sciences, CAS [QYZDJ-SSW-SLH052]

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The rapid, simple, and reliable identification of the most prevalent pathogens is essential for clinical diagnostics, biology, and food safety. Herein, four protein-encapsulated gold nanoclusters (protein-AuNCs) are designed and prepared as a sensor array for rapid identification of bacteria. The discrimination of six kinds of bacteria, including two kinds of drug-resistant bacteria, is successfully realized by the as-fabricated sensor array. The strategy presented here shows the advantages of easy synthesis and convenient to use. Furthermore, 100% classification accuracy is achieved by the sensor array consisting of two protein-AuNCs probes, demonstrating the design with sufficient diagnostic capacity. Taken together, the developed sensor array holds great promise for facile diagnosis of bacterial infection in resource-limited settings.

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