Journal
ADVANCED HEALTHCARE MATERIALS
Volume 7, Issue 13, Pages -Publisher
WILEY
DOI: 10.1002/adhm.201800155
Keywords
antibacterial; biofilms; macromolecular scaffolds; nitric oxide; rational designs
Funding
- National Institutes of Health [AI112029, DE025207]
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Exogenous nitric oxide (NO) represents an attractive antibacterial agent because of its ability to both disperse and directly kill bacterial biofilms while avoiding resistance. Due to the challenges associated with administering gaseous NO, NO-releasing macromolecular scaffolds are developed to facilitate NO delivery. This progress report describes the rational design and application of NO-releasing macromolecular scaffolds as antibacterial therapeutics. Special consideration is given to the role of the physicochemical properties of the NO storage vehicles on antibacterial or anti-biofilm activity.
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