Journal
ADVANCED HEALTHCARE MATERIALS
Volume 7, Issue 14, Pages -Publisher
WILEY
DOI: 10.1002/adhm.201800013
Keywords
Cu7.2S4; nanoparticles; photodynamic therapy; photothermal therapy; rheumatoid arthritis
Funding
- National Key Research and Development Program of China [2017YFB0702604]
- National Natural Science Foundation of China [81501859]
- Natural Science Foundation of Guangdong Province [2015A030312004]
- Science and Technology Planning Project of Guangdong Province [2014A020212668]
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Rheumatoid arthritis (RA) is a worldwide inflammatory disease that seriously threatens human health and needs more effective treatment approaches. Near infrared (NIR) light can efficiently penetrate inflamed joints affected by RA, so phototherapy, including photothermal therapy (PTT) and photodynamic therapy (PDT), may provide new opportunities. In this work, the unique Cu7.2S4 nanoparticles (NPs) are prepared for RA treatment enlightened by the fact that copper (Cu)-based nanomaterials can simultaneously serve as PTT agents and photosensitizers (for PDT). Meanwhile, Cu can promote ostogenesis and chondrogenesis. The Cu7.2S4 NPs combined with NIR (808 nm, 1 W cm(-2)) irradiation not only achieve better bone preservation, including higher bone mineral density (BMD) and bone volume/total volume, but also inhibit inflamed synovial invasion, cartilage erosion, and expression of proinflammatory cytokines in vivo. Moreover, the Cu7.2S4 NPs can effectively kill clinical pathogenic Staphylococcus aureus and Escherichia coli to prevent bacterial infection during intra-articular injection. Therefore, the combined PTT and PDT using the multifunctional Cu7.2S4 NPs could be a novel RA treatment modality with full potential.
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