Journal
ADVANCED HEALTHCARE MATERIALS
Volume 7, Issue 11, Pages -Publisher
WILEY
DOI: 10.1002/adhm.201701466
Keywords
biomimetics; biomineralization; dielectrics; thin films; tissue engineering
Funding
- National Natural Science Foundation of China [81600905]
- National Science Fund for Excellent Young Scholars [31725011]
- National Science Fund for Outstanding Young Scholars [31422022]
- Clinical Research Physician Program of Tongji Medical College, Huazhong University of Science and Technology
Ask authors/readers for more resources
Bioelectricity plays a vital role in living organisms. Although electrical stimulation is introduced in the field of bone regeneration, the concept of a dose-response relationship between surface potential and osteogenesis is not thoroughly studied. To optimize the osteogenic properties of different surface potentials, a flexible piezoelectric membrane, poly(vinylidene fluoridetrifluoroethylene) [P(VDF-TrFE)], is fabricated by annealing treatment to control its beta phases. The surface potential and piezoelectric coefficients (d(33)) of the membranes can be regulated by increasing beta phase contents. Compared with d(33) = 20 pC N-1 (surface potential = -78 mV) and unpolarized membranes, bone marrow mesenchymal stem cells (BM-MSCs) cultured on the d(33) = 10 pC N-1 (surface potential = -53 mV) membranes have better osteogenic properties. In vivo, d(33) = 10 pC N-1 membranes result in rapid bone regeneration and complete mature bone-structure formation. BM-MSCs on d(33) = 10 pC N-1 membranes have the lowest reactive oxygen species level and the highest mitochondrial membrane electric potential, implying that these membranes provide the best electrical qunantity for BM-MSCs' proliferation and energy metabolism. This study establishes an effective method to control the surface potential of P(VDF-Trfe) membranes and highlights the importance of optimized electrical stimulation in bone regeneration.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available