Journal
SYNAPTIC PLASTICITY: DYNAMICS, DEVELOPMENT AND DISEASE
Volume 970, Issue -, Pages 355-376Publisher
SPRINGER-VERLAG BERLIN
DOI: 10.1007/978-3-7091-0932-8_16
Keywords
Activity-dependent gene expression; Importins; Jacob/Nelf; Microtubule; NMDA-receptors
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The communication between synapses and the cell nucleus has attracted considerable interest for many years. This interest is largely fueled by the idea that synapse-to-nucleus signaling might specifically induce the expression of genes that make long-term memory stick. However, despite many years of research, it is still essentially unclear how synaptic signals are conveyed to the nucleus, and it remains to a large degree enigmatic how activity-induced gene expression feeds back to synaptic function. In this chapter, we will focus on the activity-dependent synapto-nuclear trafficking of protein messengers and discuss the underlying mechanisms of their retrograde transport and their supposed functional role in neuronal plasticity.
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