Journal
THERANOSTICS
Volume 8, Issue 7, Pages 1824-1849Publisher
IVYSPRING INT PUBL
DOI: 10.7150/thno.22172
Keywords
tumor; radiation therapy; metal-based nanoparticles; NanoEnhancers; radiosensitization; synergistic chemo-radiotherapy
Categories
Funding
- Ministry of Science and Technology of China [2016YFC0904600, 2015BAI01B11]
- NSFC-CAS Joint Fund for Research Based on Large-scaled Scientific Facilities (National Natural Science Foundation of China) [U1532264]
- CAS Light of West China Program (Chinese Academy of Sciences)
Ask authors/readers for more resources
Radiotherapy is one of the major therapeutic strategies for cancer treatment. In the past decade, there has been growing interest in using high Z (atomic number) elements (materials) as radiosensitizers. New strategies in nanomedicine could help to improve cancer diagnosis and therapy at cellular and molecular levels. Metal-based nanoparticles usually exhibit chemical inertness in cellular and subcellular systems and may play a role in radiosensitization and synergistic cell-killing effects for radiation therapy. This review summarizes the efficacy of metal-based NanoEnhancers against cancers in both in vitro and in vivo systems for a range of ionizing radiations including gamma-rays, X-rays, and charged particles. The potential of translating preclinical studies on metal-based nanoparticles-enhanced radiation therapy into clinical practice is also discussed using examples of several metal-based NanoEnhancers (such as CYT-6091, AGuIX, and NBTXR3). Also, a few general examples of theranostic multimetallic nanocomposites are presented, and the related biological mechanisms are discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available