Journal
CELLULAR & MOLECULAR BIOLOGY LETTERS
Volume 17, Issue 2, Pages 249-257Publisher
VERSITA
DOI: 10.2478/s11658-012-0009-4
Keywords
Autophagy; Brucella melitensis 16M; LC3-II; LC3-I; Autophagosome; Autophagy flux; 3-Methyladenine; Intracellular pathogens; Murine macrophage RAW264.7; Autophagic vesicle
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Funding
- National Basic Research Program of China (973 Program) [2010CB530203]
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This study investigated the role of autophagy in the survival of the invasive bacterium Brucella melitensis strain 16M in murine macrophages. Here, Brucella melitensis 16M was found to trigger autophagosome formation, enhance autophagy flux and increase the expression level of the autophagy marker protein LC3-II. When autophagy was pharmacologically inhibited by 3-methyladenine (3-MA), Brucella replication efficiency was significantly decreased (p < 0.05). These results suggest that autophagy favors Brucella melitensis 16M survival in murine macrophages.
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