Journal
SCIENTIFIC REPORTS
Volume 8, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-018-22360-3
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Funding
- Medical Research Council UK [MR/K003364/1]
- Northern Ireland Health and Social Care Research and Development Office [STL/4936/14]
- Department for Education and Learning, Northern Ireland
- Medical Research Council [MC_PC_15025, MC_PC_15027, MR/K003364/1] Funding Source: researchfish
- Public Health Agency [STL/3714/07, STL/4936/13, STL/4760/13] Funding Source: researchfish
- MRC [MR/K003364/1, MC_PC_15025, MC_PC_15027] Funding Source: UKRI
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The eye provides an opportunistic window to view the microcirculation. There is published evidence of an association between retinal microvascular calibre and renal function measured by estimated glomerular filtration rate (eGFR) in individuals with diabetes mellitus. Beyond vascular calibre, few studies have considered other microvascular geometrical features. Here we report novel null findings for measures of vascular spread (vessel fractal dimension), tortuosity, and branching patterns and their relationship with renal function in type 2 diabetes over a mean of 3 years. We performed a nested case-control comparison of multiple retinal vascular parameters between individuals with type 2 diabetes and stable (non-progressors) versus declining (progressors) eGFR across two time points within a subset of 1072 participants from the GoDARTS study cohort. Retinal microvascular were measured using VAMPIRE 3.1 software. In unadjusted analyses and following adjustment for age, gender, systolic blood pressure, HbA(1C), and diabetic retinopathy, no associations between baseline retinal vascular parameters and risk of eGFR progression were observed. Cross-sectional analysis of follow-up data showed a significant association between retinal arteriolar diameter and eGFR, but this was not maintained following adjustment. These findings are consistent with a lack of predictive capacity for progressive loss of renal function in type 2 diabetes.
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