4.7 Article

Large-scale brain network associated with creative insight: combined voxel-based morphometry and resting-state functional connectivity analyses

Journal

SCIENTIFIC REPORTS
Volume 8, Issue -, Pages -

Publisher

NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-018-24981-0

Keywords

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Funding

  1. ImPACT Program of the Council for Science, Technology and Innovation (Cabinet Office, Government of Japan)
  2. National Institute of Information and Communications Technology [173]
  3. New Energy and Industrial Technology Development Organization (NEDO)
  4. CREST, JST
  5. JSPS KAKENHI [26730146]
  6. Grants-in-Aid for Scientific Research [26730146] Funding Source: KAKEN

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Creative insight occurs with an Aha! experience when solving a difficult problem. Here, we investigated large-scale networks associated with insight problem solving. We recruited 232 healthy participants aged 21-69 years old. Participants completed a magnetic resonance imaging study (MRI; structural imaging and a 10 min resting-state functional MRI) and an insight test battery (ITB) consisting of written questionnaires (matchstick arithmetic task, remote associates test, and insight problem solving task). To identify the resting-state functional connectivity (RSFC) associated with individual creative insight, we conducted an exploratory voxel-based morphometry (VBM)-constrained RSFC analysis. We identified positive correlations between ITB score and grey matter volume (GMV) in the right insula and middle cingulate cortex/precuneus, and a negative correlation between ITB score and GMV in the left cerebellum crus 1 and right supplementary motor area. We applied seed-based RSFC analysis to whole brain voxels using the seeds obtained from the VBM and identified insight-positive/ negative connections, i.e. a positive/negative correlation between the ITB score and individual RSFCs between two brain regions. Insight-specific connections included motor-related regions whereas creative-common connections included a default mode network. Our results indicate that creative insight requires a coupling of multiple networks, such as the default mode, semantic and cerebral-cerebellum networks.

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