Gadoterate meglumine decreases ADC values of breast lesions depending on the b value combination

To retrospectively evaluated the influence of administration of the gadolinium based intravenous contrast agent (G-CA) on apparent diffusion coefficient (ADC) values in ADC maps generated using multiple b value combinations. A total of 106 women underwent bilateral 3.0 T breast MRI. As an internal validation, diffusion-weighted imaging (b values of 0, 200, 400, 600, 800 s/mm(2)) was performed before and after the G-CA (gadoterate meglumine (0.2 ml/kg, 3 ml/s)). Whole lesion and fibroglandular tissue (FGT) covering region-of-interests (ROIs) were drawn on the b = 800 s/mm(2) images; ROIs were then propagated to multiple retrospectively generated ADC maps. Twenty-seven patients (mean age 55.8 +/- 10.8 years) with 32 mass-like enhancing breast lesions including 25 (78.1%) histopathologically malignant lesions were enrolled. Lesion ADC values were statistically significantly higher in pre-G-CA than post-G-CA ADC maps (ADC(0,200,400,600,800): 1.05 +/- 0.35 x 10(-3) mm(2)/s vs. 1.02 +/- 0.36 x 10(-3) mm(2)/s (P < 0.05); ADC(0,200,400): 1.25 +/- 0.42 x 10(-3) mm(2)/s vs. 1.20 +/- 0.35 x 10(-3) mm(2)/s (P < 0.05)). ADC values between pre- and post-contrast maps were not statistically different when the maps were generated using other b value combinations. Contrast agent administration did not affect the FGT ADC values. G-CA statistically significantly reduced the ADC values of breast lesions on ADC maps generated using the clinically widely utilized b values.