Journal
SCIENTIFIC REPORTS
Volume 8, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-018-20513-y
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Funding
- Commonwealth Scientific Industrial and research Organization (CSIRO)
- Edith Cowan University (ECU)
- Mental Health Research institute (MHRI)
- National Ageing Research Institute (NARI)
- Austin Health
- CogState Ltd.
- National Health and Medical Research Council (NHMRC)
- Dementia Collaborative Research Centres program (DCRC2)
- Science and Industry Endowment Fund (SIEF)
- Cooperative Research Centre (CRC) for Mental Health through CRC Program, an Australian Government Initiative [20100104]
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A single nucleotide polymorphism, rs17070145, in the KIdney and BRAin expressed protein (KIBRA) gene has been associated with cognition and hippocampal volume in cognitively normal (CN) individuals. However, the impact of rs17070145 on longitudinal cognitive decline and hippocampal atrophy in CN adults at greatest risk of developing Alzheimer's disease is unknown. We investigated the impact rs17070145 has on the rate of cognitive decline and hippocampal atrophy over six years in 602 CN adults, with known brain A beta-amyloid levels and whether there is an interactive effect with APOE genotype. We reveal that whilst limited independent effects of KIBRA genotype were observed, there was an interaction with APOE in CN adults who presented with high A beta-amyloid levels across study duration. In comparison to APOE epsilon 4-ve individuals carrying the rs17070145-T allele, significantly faster rates of cognitive decline (global, p = 0.006; verbal episodic memory, p = 0.004), and hippocampal atrophy (p = 0.04) were observed in individuals who were APOE epsilon 4 + ve and did not carry the rs17070145-T allele. The observation of APOE effects in only non-carriers of the rs17070145-T allele, in the presence of high A beta-amyloid suggest that carriers of the rs17070145-T allele are conferred a level of resilience to the detrimental effects of high A beta-amyloid and APOE epsilon 4.
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